Combining chemical and genetic approaches to increase drought resistance in plants
文献类型：期刊论文
| 作者 | Cao, Min-Jie2,5; Zhang, Yu-Lu2,5; Liu, Xue2,5; Huang, Huan2,5; Zhou, X. Edward2,4,5; Wang, Wen-Long2,5; Zeng, Ai2,5; Zhao, Chun-Zhao3; Si, Tong3; Du, Jiamu2,5 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2017-10-30 |
| 卷号 | 8 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-017-01239-3 |
| 文献子类 | Article |
| 英文摘要 | Drought stress is a major threat to crop production, but effective methods to mitigate the adverse effects of drought are not available. Here, we report that adding fluorine atoms in the benzyl ring of the abscisic acid (ABA) receptor agonist AM1 optimizes its binding to ABA receptors by increasing the number of hydrogen bonds between the compound and the surrounding amino acid residues in the receptor ligand-binding pocket. The new chemicals, known as AMFs, have long-lasting effects in promoting stomatal closure and inducing the expression of stress-responsive genes. Application of AMFs or transgenic overexpression of the receptor PYL2 in Arabidopsis and soybean plants confers increased drought resistance. The greatest increase in drought resistance is achieved when AMFs are applied to the PYL2-overexpression transgenic plants. Our results demonstrate that the combining of potent chemicals with transgenic overexpression of an ABA receptor is very effective in helping plants combat drought stress. |
| WOS关键词 | ABSCISIC-ACID BIOSYNTHESIS ; 2C PROTEIN PHOSPHATASES ; ARABIDOPSIS-THALIANA ; ABA RECEPTORS ; SIGNAL-TRANSDUCTION ; COLD-ACCLIMATION ; PYL PROTEINS ; STRESS ; TOLERANCE ; EXPRESSION |
| 资助项目 | Chinese Academy of Sciences[00000000] ; Science and Technology Service Network Initiative project[KFJ-SW-STS-143] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000413894100005 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272438]  |
| 专题 | 药物靶标结构与功能中心 |
| 通讯作者 | Zhu, Jian-Kang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, VARI SIMM Ctr,Ctr Struct & Funct Drug Targets, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Ctr Plant Stress Biol, 300 Fenglin Rd, Shanghai 200032, Peoples R China; 3.Purdue Univ, Dept Hort & Landscape Architecture, W Lafayette, IN 47907 USA; 4.Van Andel Res Inst, Ctr Struct Biol & Drug Discovery, Lab Struct Sci, 333 Bostwick Ave NE, Grand Rapids, MI 49503 USA; 5.Chinese Acad Sci, Ctr Excellence Mol Plant Sci, 300 Fenglin Rd, Shanghai 200032, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Cao, Min-Jie,Zhang, Yu-Lu,Liu, Xue,et al. Combining chemical and genetic approaches to increase drought resistance in plants[J]. NATURE COMMUNICATIONS,2017,8. |
| APA | Cao, Min-Jie.,Zhang, Yu-Lu.,Liu, Xue.,Huang, Huan.,Zhou, X. Edward.,...&Zhu, Jian-Kang.(2017).Combining chemical and genetic approaches to increase drought resistance in plants.NATURE COMMUNICATIONS,8. |
| MLA | Cao, Min-Jie,et al."Combining chemical and genetic approaches to increase drought resistance in plants".NATURE COMMUNICATIONS 8(2017). |
入库方式： OAI收割
来源：上海药物研究所
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