One-pot synthesis of 2,3-difunctionalized indoles via Rh(III)-catalyzed carbenoid insertion C-H activation/cyclization
文献类型：期刊论文
| 作者 | Lv, Honggui1,2,3,4; Shi, Jingjing4 ; Wu, Bo1,2; Guo, Yujuan1,2; Huang, Junjun1,2; Yi, Wei1,2,4
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| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2017-10-14 |
| 卷号 | 15期号:38页码:8054-8058 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/c7ob01977g |
| 文献子类 | Article |
| 英文摘要 | Reported herein is the first Rh(III)-catalyzed carbenoid insertion C-H activation/cyclization of N-arylureas and alpha-diazo beta-keto esters. The redox-neutral reaction has the following features: good to excellent yields, broad substrate/functional group tolerance, exclusive regioselectivity, and no need for additional oxidants or additives, which render this methodology as a more efficient and versatile alternative to the existing methods for the synthesis of 2,3-difunctionalized indoles. |
| WOS关键词 | DIAZO CARBONYL-COMPOUNDS ; N BOND-CLEAVAGE ; DIRECTING GROUP ; REGIOSELECTIVE SYNTHESIS ; MIGRATORY INSERTION ; UNPROTECTED INDOLES ; EFFICIENT SYNTHESIS ; INTERNAL ALKYNES ; ROOM-TEMPERATURE ; ARYL UREAS |
| 资助项目 | NSFC[81502909] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000412826500011 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272450]  |
| 专题 | 药物靶标结构与功能中心 |
| 通讯作者 | Yi, Wei |
| 作者单位 | 1.Guangzhou Med Univ, Key Lab Mol Clin Pharmacol, Guangzhou 511436, Guangdong, Peoples R China; 2.Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou 511436, Guangdong, Peoples R China; 3.Shanghai Univ, Dept Chem, 99 Shang Da Rd, Shanghai 200444, Peoples R China 4.Chinese Acad Sci, CAS Key Lab Receptor Res, VARI SIMM Ctr, Ctr Struct & Funct Drug Targets,Shanghai Inst Mat, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Lv, Honggui,Shi, Jingjing,Wu, Bo,et al. One-pot synthesis of 2,3-difunctionalized indoles via Rh(III)-catalyzed carbenoid insertion C-H activation/cyclization[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2017,15(38):8054-8058. |
| APA | Lv, Honggui,Shi, Jingjing,Wu, Bo,Guo, Yujuan,Huang, Junjun,&Yi, Wei.(2017).One-pot synthesis of 2,3-difunctionalized indoles via Rh(III)-catalyzed carbenoid insertion C-H activation/cyclization.ORGANIC & BIOMOLECULAR CHEMISTRY,15(38),8054-8058. |
| MLA | Lv, Honggui,et al."One-pot synthesis of 2,3-difunctionalized indoles via Rh(III)-catalyzed carbenoid insertion C-H activation/cyclization".ORGANIC & BIOMOLECULAR CHEMISTRY 15.38(2017):8054-8058. |
入库方式： OAI收割
来源：上海药物研究所
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