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Amyloid beta: structure, biology and structure-based therapeutic development
文献类型：期刊论文
| 作者 | Chen, Guo-fang1; Xu, Ting-hai1; Yan, Yan1; Zhou, Yu-ren1; Jiang, Yi1 ; Melcher, Karsten2; Xu, H. Eric1,2
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| 刊名 | ACTA PHARMACOLOGICA SINICA
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| 出版日期 | 2017-09 |
| 卷号 | 38期号:9页码:1205-1235 |
| 关键词 | amyloid beta peptide amyloid precursor protein Alzheimer's disease neurodegenerative diseases drug discovery |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2017.28 |
| 文献子类 | Review |
| 英文摘要 | Amyloid beta peptide (A beta) is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by beta- and gamma-secretases. A beta accumulation in the brain is proposed to be an early toxic event in the pathogenesis of Alzheimer's disease, which is the most common form of dementia associated with plaques and tangles in the brain. Currently, it is unclear what the physiological and pathological forms of A beta are and by what mechanism A beta causes dementia. Moreover, there are no efficient drugs to stop or reverse the progression of Alzheimer's disease. In this paper, we review the structures, biological functions, and neurotoxicity role of A beta. We also discuss the potential receptors that interact with A beta and mediate A beta intake, clearance, and metabolism. Additionally, we summarize the therapeutic developments and recent advances of different strategies for treating Alzheimer's disease. Finally, we will report on the progress in searching for novel, potentially effective agents as well as selected promising strategies for the treatment of Alzheimer's disease. These prospects include agents acting on A beta, its receptors and tau protein, such as small molecules, vaccines and antibodies against A beta; inhibitors or modulators of beta- and beta-secretase; A beta-degrading proteases; tau protein inhibitors and vaccines; amyloid dyes and microRNAs. |
| WOS关键词 | BLOOD-BRAIN-BARRIER ; INSULIN-DEGRADING ENZYME ; SOLID-STATE NMR ; NICOTINIC ACETYLCHOLINE-RECEPTORS ; METABOTROPIC GLUTAMATE RECEPTORS ; ATOMIC-FORCE MICROSCOPY ; GAMMA-SECRETASE COMPLEX ; SMOOTH-MUSCLE-CELLS ; AMELIORATES MEMORY IMPAIRMENT ; ENDOTHELIN-CONVERTING ENZYME |
| 资助项目 | Postdoctoral Science Foundation of China[Y512031078] ; National Natural Science Foundation of China[31300607] ; Shanghai Science and Technology Committee[13ZR1447600] ; Jay and Betty Van Andel Foundation, Amway (China)[00000000] ; Ministry of Science and Technology of China[2012CB910403] ; Ministry of Science and Technology of China[2013CB910601] ; Ministry of Science and Technology of China[XDB08020303] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6054167 |
| WOS记录号 | WOS:000410575900001 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272503]  |
| 专题 | 药物靶标结构与功能中心 |
| 通讯作者 | Chen, Guo-fang; Xu, H. Eric |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Ctr Struct & Funct Drug Targets,VARI SIMM Ctr, Shanghai 201203, Peoples R China; 2.Van Andel Res Inst, Lab Struct Sci, Grand Rapids, MI 49503 USA |
| 推荐引用方式 GB/T 7714 | Chen, Guo-fang,Xu, Ting-hai,Yan, Yan,et al. Amyloid beta: structure, biology and structure-based therapeutic development[J]. ACTA PHARMACOLOGICA SINICA,2017,38(9):1205-1235. |
| APA | Chen, Guo-fang.,Xu, Ting-hai.,Yan, Yan.,Zhou, Yu-ren.,Jiang, Yi.,...&Xu, H. Eric.(2017).Amyloid beta: structure, biology and structure-based therapeutic development.ACTA PHARMACOLOGICA SINICA,38(9),1205-1235. |
| MLA | Chen, Guo-fang,et al."Amyloid beta: structure, biology and structure-based therapeutic development".ACTA PHARMACOLOGICA SINICA 38.9(2017):1205-1235. |
入库方式： OAI收割
来源：上海药物研究所
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