Diversity-oriented synthesis of natural product-like libraries
文献类型：期刊论文
| 作者 | Liu Gang; Li Yulin; Nan Fajun
|
| 刊名 | PROGRESS IN CHEMISTRY
 |
| 出版日期 | 2006-06 |
| 卷号 | 18期号:6页码:734-742 |
| 关键词 | diversity-oriented synthesis (DOS) natural product-like libraries target-oriented synthesis |
| ISSN号 | 1005-281X |
| 文献子类 | Article |
| 英文摘要 | Natural products provide the most important sources of lead compounds in drug discovery. With the development of high-throughput screening (HTS) technology and in depth studies in chemical biology, exploring pharmaceutically relevant chemical space of natural products is vital. Employing diversity-oriented synthesis (DOS) to construct skeletally complex natural product-like libraries and using it in the studies of chemical biology and lead discovery is becoming a tendency. The development of exceptionally efficient, stereoselective, and chemoselective reactions that can be applied to a wide range of substrates play key roles. |
| WOS关键词 | SOLID-PHASE SYNTHESIS ; SMALL ORGANIC-MOLECULES ; COMBINATORIAL SYNTHESIS ; DRUG DISCOVERY ; PRIVILEGED STRUCTURES ; BENZOPYRAN LIBRARIES ; CHEMICAL GENETICS ; CLICK CHEMISTRY ; CELL-CYCLE ; INHIBITORS |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2505355 |
| WOS记录号 | WOS:000238548200007 |
| 出版者 | CHINESE ACAD SCIENCES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273584]  |
| 专题 | 国家新药筛选中心 |
| 通讯作者 | Liu Gang |
| 作者单位 | 1.Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Chinese Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 2.Lanzhou Univ, Inst Organ Chem, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu Gang,Li Yulin,Nan Fajun. Diversity-oriented synthesis of natural product-like libraries[J]. PROGRESS IN CHEMISTRY,2006,18(6):734-742. |
| APA | Liu Gang,Li Yulin,&Nan Fajun.(2006).Diversity-oriented synthesis of natural product-like libraries.PROGRESS IN CHEMISTRY,18(6),734-742. |
| MLA | Liu Gang,et al."Diversity-oriented synthesis of natural product-like libraries".PROGRESS IN CHEMISTRY 18.6(2006):734-742. |
入库方式： OAI收割
来源：上海药物研究所
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