Structural Studies of G Protein-Coupled Receptors
文献类型：期刊论文
| 作者 | Lu, Mengjie1,2; Wu, Beili1,3
|
| 刊名 | IUBMB LIFE
 |
| 出版日期 | 2016-11 |
| 卷号 | 68期号:11页码:894-903 |
| 关键词 | G protein-coupled receptor structural studies chemokine receptor purinergic receptor |
| ISSN号 | 1521-6543 |
| DOI | 10.1002/iub.1578 |
| 文献子类 | Review |
| 英文摘要 | G protein-coupled receptors (GPCRs) comprise the largest membrane protein family. These receptors sense a variety of signaling molecules, activate multiple intracellular signal pathways, and act as the targets of over 40% of marketed drugs. Recent progress on GPCR structural studies provides invaluable insights into the structure-function relationship of the GPCR superfamily, deepening our understanding about the molecular mechanisms of GPCR signal transduction. Here, we review recent breakthroughs on GPCR structure determination and the structural features of GPCRs, and take the structures of chemokine receptor CCR5 and purinergic receptors P2Y(1)R and P2Y(12)R as examples to discuss the importance of GPCR structures on functional studies and drug discovery. In addition, we discuss the prospect of GPCR structure-based drug discovery. (C) 2016 IUBMB Life |
| WOS关键词 | MUSCARINIC ACETYLCHOLINE-RECEPTOR ; STRUCTURE-BASED DISCOVERY ; SERIAL FEMTOSECOND CRYSTALLOGRAPHY ; RESOLUTION CRYSTAL-STRUCTURE ; A(2A) ADENOSINE RECEPTOR ; HISTAMINE H-1 RECEPTOR ; HUMAN P2Y(12) RECEPTOR ; OPIOID RECEPTOR ; ALLOSTERIC MODULATION ; SEROTONIN RECEPTORS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000388441400009 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275832]  |
| 专题 | 药物靶标结构与功能中心 |
| 通讯作者 | Wu, Beili |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 2.Univ Chinese Acad Sci, Beijing, Peoples R China; 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Mengjie,Wu, Beili. Structural Studies of G Protein-Coupled Receptors[J]. IUBMB LIFE,2016,68(11):894-903. |
| APA | Lu, Mengjie,&Wu, Beili.(2016).Structural Studies of G Protein-Coupled Receptors.IUBMB LIFE,68(11),894-903. |
| MLA | Lu, Mengjie,et al."Structural Studies of G Protein-Coupled Receptors".IUBMB LIFE 68.11(2016):894-903. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。