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Structures and regulation of non-X orphan nuclear receptors: A retinoid hypothesis

文献类型：期刊论文

作者Zhi, Xiaoyong1,3; Zhou, X. Edward3; Melcher, Karsten3; Xu, H. Eric2,3
刊名JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
出版日期2016-03
卷号157页码:27-40
关键词Orphan nuclear receptor Ligand Crystal structure Gene repression
ISSN号0960-0760
DOI10.1016/j.jsbmb.2015.06.012
文献子类Article
英文摘要Nuclear receptors are defined as a family of ligand regulated transcription factors [1-6]. While this definition reflects that ligand binding is a key property of nuclear receptors, it is still a heated subject of debate if all the nuclear receptors (48 human members) can bind ligands (ligands referred here to both physiological and synthetic ligands). Recent studies in nuclear receptor structure biology and pharmacology have undoubtedly increased our knowledge of nuclear receptor functions and their regulation. As a result, they point to new avenues for the discovery and development of nuclear receptor regulators, including nuclear receptor ligands. Here we review the recent literature on orphan nuclear receptor structural analysis and ligand identification, particularly on the orphan nuclear receptors that do not heterodimerize with retinoid X receptors, which we term as non-X orphan receptors. We also propose a speculative "retinoid hypothesis" for a subset of non-X orphan nuclear receptors, which we hope to help shed light on orphan nuclear receptor biology and drug discovery. This article is part of a Special Issue entitled 'Orphan Nuclear Receptors'. (C) 2015 Elsevier Ltd. All rights reserved.
WOS关键词SMALL HETERODIMER PARTNER ; STEROIDOGENIC FACTOR-I ; BILE-ACID BIOSYNTHESIS ; LIGAND-BINDING DOMAIN ; NEURAL STEM-CELLS ; PROMOTER-TRANSCRIPTION FACTORS ; ADRENAL HYPOPLASIA CONGENITA ; ACTIVATED ESTROGEN-RECEPTORS ; NEGATIVE FEEDBACK-REGULATION ; LXXLL-RELATED MOTIFS
WOS研究方向Biochemistry & Molecular Biology ; Endocrinology & Metabolism
语种英语
WOS记录号WOS:000369214900006
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/276131]  
专题药物靶标结构与功能中心
通讯作者Zhi, Xiaoyong; Xu, H. Eric
作者单位1.Univ Texas SW Med Ctr Dallas, Autophagy Res Ctr, 6000 Harry Hines Blvd, Dallas, TX 75390 USA;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, VARI SIMM Ctr, Shanghai 201203, Peoples R China
3.Van Andel Res Inst, Lab Struct Sci, 333 Bostwick Ave NE, Grand Rapids, MI 49503 USA;
推荐引用方式
GB/T 7714		 Zhi, Xiaoyong,Zhou, X. Edward,Melcher, Karsten,et al. Structures and regulation of non-X orphan nuclear receptors: A retinoid hypothesis[J]. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY,2016,157:27-40.
APA Zhi, Xiaoyong,Zhou, X. Edward,Melcher, Karsten,&Xu, H. Eric.(2016).Structures and regulation of non-X orphan nuclear receptors: A retinoid hypothesis.JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY,157,27-40.
MLA Zhi, Xiaoyong,et al."Structures and regulation of non-X orphan nuclear receptors: A retinoid hypothesis".JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 157(2016):27-40.

入库方式： OAI收割

来源：上海药物研究所

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