A new and efficient ZnCl2-catalyzed synthesis and biological evaluation of novel 2-amino-3,5-dicyano-4-ary1-6-aryl-aminopyridines as potent antibacterial agents against Helicobacter pylori (HP)
文献类型：期刊论文
| 作者 | Huang, Jijun3; Zhou, Jie3; Song, Senchuan3; Song, Huacan3; Chen, Zhiyong2; Yi, Wei1 |
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2015-11-11 |
| 卷号 | 71期号:45页码:8628-8636 |
| 关键词 | ZnCl2-catalyzed cyclization 2,6-Diamino-3,5-dicyano-4-aiylpyridines Antibacterial activity Helicobacter Pylori (HP) |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2015.09.018 |
| 文献子类 | Article |
| 英文摘要 | Here a new and efficient method via ZnCl2-catalyzed direct cyclization of diverse benzylidenemalononitriles and arylamines has been developed. With this method, a variety of novel 2-amino-3,5-dicyano-4-aryl-6-aryl-aminopyridines (2a-2v) could be easily prepared under the mild conditions with board substrate/functional group tolerance and decent product yields. The biological activities of the selected compounds (2c, 2e, 2g, 2i, 2k, 2m, 2n and 20) has also been evaluated as new antibacterial agents. The results demonstrated that almost all of the compounds had more potent antibacterial activities against HP than that of clinically used drugs, Ornidazole, Metronidazole, Nitrimidazine and Clarithromycin, suggesting that further development of such compounds might be of great interest. (C) 2015 Elsevier Ltd. All rights reserved. |
| WOS关键词 | DERIVATIVES ; INHIBITORS ; DISCOVERY |
| 资助项目 | Chinese Postdoctoral Science Foundation[2012M511158] ; Chinese Postdoctoral Science Foundation[2013T60477] ; National Natural Science Foundation of China[81125023] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000363080800017 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276326]  |
| 专题 | 药物靶标结构与功能中心 |
| 通讯作者 | Song, Huacan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, VARI SIMM Ctr, CAS Key Lab Receptor Res,Ctr Struct & Funct Drug, Shanghai 201203, Peoples R China 2.China Natl Analyt Ctr Guangzhou, Guangdong Prov Publ Lab Anal & Testing Technol, Guangzhou 510070, Guangdong, Peoples R China; 3.Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Huang, Jijun,Zhou, Jie,Song, Senchuan,et al. A new and efficient ZnCl2-catalyzed synthesis and biological evaluation of novel 2-amino-3,5-dicyano-4-ary1-6-aryl-aminopyridines as potent antibacterial agents against Helicobacter pylori (HP)[J]. TETRAHEDRON,2015,71(45):8628-8636. |
| APA | Huang, Jijun,Zhou, Jie,Song, Senchuan,Song, Huacan,Chen, Zhiyong,&Yi, Wei.(2015).A new and efficient ZnCl2-catalyzed synthesis and biological evaluation of novel 2-amino-3,5-dicyano-4-ary1-6-aryl-aminopyridines as potent antibacterial agents against Helicobacter pylori (HP).TETRAHEDRON,71(45),8628-8636. |
| MLA | Huang, Jijun,et al."A new and efficient ZnCl2-catalyzed synthesis and biological evaluation of novel 2-amino-3,5-dicyano-4-ary1-6-aryl-aminopyridines as potent antibacterial agents against Helicobacter pylori (HP)".TETRAHEDRON 71.45(2015):8628-8636. |
入库方式： OAI收割
来源：上海药物研究所
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