Structural Studies of G Protein-Coupled Receptors
文献类型：期刊论文
| 作者 | Zhang, Dandan; Zhao, Qiang ; Wu, Beili
|
| 刊名 | MOLECULES AND CELLS
 |
| 出版日期 | 2015-10 |
| 卷号 | 38期号:10页码:836-842 |
| 关键词 | activation allosteric modulation GPCR ligand recognition structure |
| ISSN号 | 1016-8478 |
| DOI | 10.14348/molcells.2015.0263 |
| 文献子类 | Review |
| 英文摘要 | G protein-coupled receptors (GPCRs) constitute the largest and the most physiologically important membrane protein family that recognizes a variety of environmental stimuli, and are drug targets in the treatment of numerous diseases. Recent progress on GPCR structural studies shed light on molecular mechanisms of GPCR ligand recognition, activation and allosteric modulation, as well as structural basis of GPCR dimerization. In this review, we will discuss the structural features of GPCRs and structural insights of different aspects of GPCR biological functions. |
| WOS关键词 | MUSCARINIC ACETYLCHOLINE-RECEPTOR ; RESOLUTION CRYSTAL-STRUCTURE ; A(2A) ADENOSINE RECEPTOR ; HUMAN P2Y(12) RECEPTOR ; OPIOID RECEPTOR ; SEROTONIN RECEPTORS ; MEMBRANE-PROTEINS ; COMPLEX ; GPCR ; ANTAGONIST |
| 资助项目 | CAS Strategic Priority Research Program[XDB08020300] ; National Science Foundation of China[31422017] ; National Science Foundation of China[31370729] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000364586200002 |
| 出版者 | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276377]  |
| 专题 | 药物靶标结构与功能中心 |
| 通讯作者 | Wu, Beili |
| 作者单位 | Chinese Acad Sci, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Dandan,Zhao, Qiang,Wu, Beili. Structural Studies of G Protein-Coupled Receptors[J]. MOLECULES AND CELLS,2015,38(10):836-842. |
| APA | Zhang, Dandan,Zhao, Qiang,&Wu, Beili.(2015).Structural Studies of G Protein-Coupled Receptors.MOLECULES AND CELLS,38(10),836-842. |
| MLA | Zhang, Dandan,et al."Structural Studies of G Protein-Coupled Receptors".MOLECULES AND CELLS 38.10(2015):836-842. |
入库方式： OAI收割
来源：上海药物研究所
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