Abscisic acid perception and signaling: structural mechanisms and applications
文献类型：期刊论文
| 作者 | Ng, Ley Moy4; Melcher, Karsten3; Teh, Bin Tean1,4,5; Xu, H. Eric2,3
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| 刊名 | ACTA PHARMACOLOGICA SINICA
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| 出版日期 | 2014-05 |
| 卷号 | 35期号:5页码:567-584 |
| 关键词 | abscisic acid abiotic stress ABA receptor plant hormone |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2014.5 |
| 文献子类 | Review |
| 英文摘要 | Adverse environmental conditions are a threat to agricultural yield and therefore exert a global effect on livelihood, health and the economy. Abscisic acid (ABA) is a vital plant hormone that regulates abiotic stress tolerance, thereby allowing plants to cope with environmental stresses. Previously, attempts to develop a complete understanding of the mechanisms underlying ABA signaling have been hindered by difficulties in the identification of bona fide ABA receptors. The discovery of the PYR/PYL/RCAR family of ABA receptors therefore represented a major milestone in the effort to overcome these roadblocks; since then, many structural and functional studies have provided detailed insights into processes ranging from ABA perception to the activation of ABA-responsive gene transcription. This understanding of the mechanisms of ABA perception and signaling has served as the basis for recent, preliminary developments in the genetic engineering of stress-resistant crops as well as in the design of new synthetic ABA agonists, which hold great promise for the agricultural enhancement of stress tolerance. |
| WOS关键词 | PROTEIN PHOSPHATASE 2C ; ABA-INDEPENDENT INHIBITION ; REGULATED GENE-EXPRESSION ; OSMOTIC-STRESS RESPONSES ; ARABIDOPSIS-THALIANA ; TRANSCRIPTION FACTORS ; MOLECULAR-BASIS ; SNRK2 KINASES ; GUARD-CELLS ; SELECTIVE ACTIVATION |
| 资助项目 | NIGMS NIH HHS[R01 GM102545] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000335447000002 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277098]  |
| 专题 | 药物靶标结构与功能中心 |
| 通讯作者 | Ng, Ley Moy |
| 作者单位 | 1.Duke Natl Univ Singapore, Div Canc & Stem Cell Biol, Grad Sch Med, Singapore, Singapore; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, VARI SIMM Ctr,Ctr Struct & Funct Drug Targets, Shanghai 201203, Peoples R China 3.Van Andel Res Inst, Ctr Struct Biol & Drug Discovery, Lab Struct Sci, Grand Rapids, MI 49503 USA; 4.Natl Univ Singapore, Canc Sci Inst Singapore, Singapore 117599, Singapore; 5.Natl Canc Ctr Singapore, Div Med Sci, Lab Canc Epigenome, Singapore, Singapore; |
| 推荐引用方式 GB/T 7714 | Ng, Ley Moy,Melcher, Karsten,Teh, Bin Tean,et al. Abscisic acid perception and signaling: structural mechanisms and applications[J]. ACTA PHARMACOLOGICA SINICA,2014,35(5):567-584. |
| APA | Ng, Ley Moy,Melcher, Karsten,Teh, Bin Tean,&Xu, H. Eric.(2014).Abscisic acid perception and signaling: structural mechanisms and applications.ACTA PHARMACOLOGICA SINICA,35(5),567-584. |
| MLA | Ng, Ley Moy,et al."Abscisic acid perception and signaling: structural mechanisms and applications".ACTA PHARMACOLOGICA SINICA 35.5(2014):567-584. |
入库方式： OAI收割
来源：上海药物研究所
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