Water as a green solvent for efficient synthesis of isocoumarins through microwave-accelerated and Rh/Cu-catalyzed C-H/O-H bond functionalization
文献类型：期刊论文
| 作者 | Li, Qiu1,2; Yan, Yunnan1,4; Wang, Xiaowei1,5; Gong, Binwei1,5; Tang, Xiaobo1; Shi, JingJing1 ; Xu, H. Eric1,3; Yi, Wei1
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| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2013 |
| 卷号 | 3期号:45页码:23402-23408 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c3ra43175d |
| 文献子类 | Article |
| 英文摘要 | Green chemistry that uses water as a solvent has recently received great attention in organic synthesis. Here we report an efficient synthesis of biologically important isocoumarins through direct cleavage of C-H/O-H bonds by microwave-accelerated and Rh/Cu-catalyzed oxidative annulation of various substituted benzoic acids, where water is used as the only solvent in the reactions. The remarkable features of this "green" methodology include high product yields, wide tolerance of various functional groups as substrates, and excellent region-/site-specificities, thus rendering this methodology a highly versatile and eco-friendly alternative to the existing methods for synthesizing isocoumarins and other biologically important derivatives such as isoquinolones. |
| WOS关键词 | HYDRANGEAE DULCIS FOLIUM ; ONE-POT SYNTHESIS ; ORGANIC-SYNTHESIS ; LACTONIZATION SEQUENCE ; ISOQUINOLINIUM SALTS ; ROOM-TEMPERATURE ; CARBOXYLIC-ACIDS ; N-CHLOROAMINES ; BENZOIC-ACIDS ; ON-WATER |
| 资助项目 | Jay and Betty Van Andel Foundation[00000000] ; Amway (China)[00000000] ; Chinese Postdoctoral Science Foundation[2012M511158] ; Chinese Postdoctoral Science Foundation[2013T60477] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000326395800096 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277782]  |
| 专题 | 药物靶标结构与功能中心 |
| 通讯作者 | Yi, Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, VARI SIMM Ctr,Ctr Struct & Funct Drug Targets, Shanghai 201203, Peoples R China; 2.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Jiangsu, Peoples R China; 3.Van Andel Res Inst, Program Struct Biol & Drug Discovery, Lab Struct Sci, Grand Rapids, MI 49503 USA; 4.Gannan Med Univ, Coll Pharmaceut Sci, Ganzhou 341000, Jiangxi, Peoples R China; 5.Shenyang Univ Chem Technol, Coll Pharmaceut & Biol Engn, Shenyang 110142, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Qiu,Yan, Yunnan,Wang, Xiaowei,et al. Water as a green solvent for efficient synthesis of isocoumarins through microwave-accelerated and Rh/Cu-catalyzed C-H/O-H bond functionalization[J]. RSC ADVANCES,2013,3(45):23402-23408. |
| APA | Li, Qiu.,Yan, Yunnan.,Wang, Xiaowei.,Gong, Binwei.,Tang, Xiaobo.,...&Yi, Wei.(2013).Water as a green solvent for efficient synthesis of isocoumarins through microwave-accelerated and Rh/Cu-catalyzed C-H/O-H bond functionalization.RSC ADVANCES,3(45),23402-23408. |
| MLA | Li, Qiu,et al."Water as a green solvent for efficient synthesis of isocoumarins through microwave-accelerated and Rh/Cu-catalyzed C-H/O-H bond functionalization".RSC ADVANCES 3.45(2013):23402-23408. |
入库方式： OAI收割
来源：上海药物研究所
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