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Troglitazone inhibits cell proliferation by attenuation of epidermal growth factor receptor signaling independent of peroxisome proliferator-activated receptor gamma

文献类型：期刊论文

作者Li, Xiaoqi1,2; Yang, Xuanming1,2; Xu, Youli1,2; Jiang, Xuejun4; Li, Xin3; Nan, Fajun3; Tang, Hong1,2
刊名CELL RESEARCH
出版日期2009-06
卷号19期号:6页码:720-732
关键词EGFR PPAR gamma troglitazone endocytosis growth arrest
ISSN号1001-0602
DOI10.1038/cr.2009.53
文献子类Article
英文摘要Peroxisome proliferator-activated receptors (PPAR) belong to the nuclear hormone receptor superfamily of ligand-dependent transcription factors. Recent results have shown that agonists of PPAR gamma, such as troglitazone (TGZ), can inhibit cell proliferation and promote cell differentiation independent of PPAR gamma. In the present study, we provide evidence that TGZ may bind directly to EGFR and trigger its signaling and internalization independent of PPAR gamma. Detailed studies revealed that prolonged incubation with TGZ effectively attenuated EGFR signaling by targeting the receptor to the endo-lysosomal degradation machinery. Although the extracellular signal-regulated kinase-signaling pathway was transiently activated by TGZ in EGFR overexpressing cancer cells, inhibition of EGF-induced Akt phosphorylation most likely accounted for the growth arrest of tumor cells caused by TGZ at pharmacologically achievable concentrations. Therefore, we have provided a new line of evidence indicating that TGZ inhibits cell proliferation by promoting EGFR degradation and attenuating Akt phosphorylation.
WOS关键词BREAST-CANCER CELLS ; PPAR-GAMMA ; ENDOTHELIAL-CELLS ; PROTEIN-KINASE ; IN-VITRO ; PROSTATE-CANCER ; LUNG-CANCER ; APOPTOSIS ; ENDOCYTOSIS ; LIGAND
资助项目Ministry of Science and Technology, China[2007DFC30190] ; Chinese Academy of Sciences[kscx-1-YW-10]
WOS研究方向Cell Biology
语种英语
CSCD记录号CSCD:3615826
WOS记录号WOS:000266528000006
出版者INST BIOCHEMISTRY & CELL BIOLOGY
源URL[http://119.78.100.183/handle/2S10ELR8/279224]  
专题国家新药筛选中心
通讯作者Tang, Hong
作者单位1.Chinese Acad Sci, Inst Biophys, Ctr Infect & Immun, Beijing 100101, Peoples R China;
2.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
4.Chinese Acad Sci, Inst Microbiol, Beijing 100080, Peoples R China
推荐引用方式
GB/T 7714		 Li, Xiaoqi,Yang, Xuanming,Xu, Youli,et al. Troglitazone inhibits cell proliferation by attenuation of epidermal growth factor receptor signaling independent of peroxisome proliferator-activated receptor gamma[J]. CELL RESEARCH,2009,19(6):720-732.
APA Li, Xiaoqi.,Yang, Xuanming.,Xu, Youli.,Jiang, Xuejun.,Li, Xin.,...&Tang, Hong.(2009).Troglitazone inhibits cell proliferation by attenuation of epidermal growth factor receptor signaling independent of peroxisome proliferator-activated receptor gamma.CELL RESEARCH,19(6),720-732.
MLA Li, Xiaoqi,et al."Troglitazone inhibits cell proliferation by attenuation of epidermal growth factor receptor signaling independent of peroxisome proliferator-activated receptor gamma".CELL RESEARCH 19.6(2009):720-732.

入库方式： OAI收割

来源：上海药物研究所

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