Structure and Physiological Regulation of AMPK
文献类型：期刊论文
| 作者 | Yan, Yan1,2; Zhou, X. Edward2; Xu, H. Eric1,2 ; Melcher, Karsten2
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| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2018-11 |
| 卷号 | 19期号:11 |
| 关键词 | energy metabolism AMPK activation loop AID -linker -linker CBS LKB1 CaMKK2 RIM |
| ISSN号 | 1422-0067 |
| DOI | 10.3390/ijms19113534 |
| 文献子类 | Review |
| 英文摘要 | Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a heterotrimeric complex that functions as a central regulator of energy homeostasis. Energy stress manifests as a drop in the ratio of adenosine triphosphate (ATP) to AMP/ADP, which activates AMPK's kinase activity, allowing it to upregulate ATP-generating catabolic pathways and to reduce energy-consuming catabolic pathways and cellular programs. AMPK senses the cellular energy state by competitive binding of the three adenine nucleotides AMP, ADP, and ATP to three sites in its subunit, each, which in turn modulates the activity of AMPK's kinase domain in its subunit. Our current understanding of adenine nucleotide binding and the mechanisms by which differential adenine nucleotide occupancies activate or inhibit AMPK activity has been largely informed by crystal structures of AMPK in different activity states. Here we provide an overview of AMPK structures, and how these structures, in combination with biochemical, biophysical, and mutational analyses provide insights into the mechanisms of adenine nucleotide binding and AMPK activity modulation. |
| WOS关键词 | ACTIVATED PROTEIN-KINASE ; ENERGY SENSOR ; PHOSPHORYLATION ; MECHANISM ; SUBUNIT ; BINDING ; ALPHA ; UPSTREAM ; DOMAIN ; DRUGS |
| 资助项目 | Van Andel Research Institute[00000000] ; National Institutes of Health[R01 GM129436] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000451528500250 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279503]  |
| 专题 | 药物靶标结构与功能中心 |
| 通讯作者 | Melcher, Karsten |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, VARI SIMM Ctr,Ctr Struct & Funct Drug Targets, Shanghai 201203, Peoples R China 2.Van Andel Res Inst, Ctr Canc & Cell Biol, 333 Bostwick Ave NE, Grand Rapids, MI 49503 USA; |
| 推荐引用方式 GB/T 7714 | Yan, Yan,Zhou, X. Edward,Xu, H. Eric,et al. Structure and Physiological Regulation of AMPK[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2018,19(11). |
| APA | Yan, Yan,Zhou, X. Edward,Xu, H. Eric,&Melcher, Karsten.(2018).Structure and Physiological Regulation of AMPK.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,19(11). |
| MLA | Yan, Yan,et al."Structure and Physiological Regulation of AMPK".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19.11(2018). |
入库方式： OAI收割
来源：上海药物研究所
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