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Hydroxyl Group-Prompted and Iridium(III)-Catalyzed Regioselective C-H Annulation of N-phenoxyacetamides with Propargyl Alcohols

文献类型：期刊论文

作者Chen, Weijie2,4; Liu, Fu-Xiaomin2,4; Gong, Wanchun1; Zhou, Zhi2,4; Gao, Hui2,4; Shi, Jingjing3; Wu, Bo2,4; Yi, Wei2,4
刊名ADVANCED SYNTHESIS & CATALYSIS
出版日期2018-07-04
卷号360期号:13页码:2470-2475
关键词Iridium(III) catalysts C-H annulation N-phenoxyacetamides tertiary propargyl alcohols benzofurans
ISSN号1615-4150
DOI10.1002/adsc.201800322
文献子类Article
英文摘要An efficient, mild and redox-neutral iridium(III)-catalyzed C-H annulation of N-phenoxyacetamides for the regioselective synthesis of benzofurans has been developed by employing tertiary propargyl alcohols as the versatile coupling partners. The computed results together with the experimental data revealed that the hydroxyl group of tertiary propargyl alcohols acts as the key factor in controlling the regioselectivity and tuning the reactivity.
WOS关键词CATALYZED ASYMMETRIC HYDROGENATION ; INTERNAL ALKYNES ; BOND ACTIVATION ; EFFICIENT SYNTHESIS ; ROOM-TEMPERATURE ; FUNCTIONALIZATION ; ALKENES ; MILD ; ISOQUINOLINES ; DERIVATIVES
资助项目NSFC[81502909] ; Guangdong Natural Science Funds for Distinguished Young Scholar[2017A030306031]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000437261300009
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/279665]  
专题药物靶标结构与功能中心
通讯作者Zhou, Zhi; Wu, Bo; Yi, Wei
作者单位1.Shanghai Pharmaceut Holding Co Ltd, Cent Res Inst, Shanghai 201203, Peoples R China;
2.Guangzhou Med Univ, Sch Pharmaceut Sci, Key Lab Mol Target & Clin Pharmacol, Guangzhou 511436, Guangdong, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, VARI SIMM Ctr,Ctr Struct & Funct Drug Targets, Shanghai 201203, Peoples R China
4.Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou 511436, Guangdong, Peoples R China;
推荐引用方式
GB/T 7714		 Chen, Weijie,Liu, Fu-Xiaomin,Gong, Wanchun,et al. Hydroxyl Group-Prompted and Iridium(III)-Catalyzed Regioselective C-H Annulation of N-phenoxyacetamides with Propargyl Alcohols[J]. ADVANCED SYNTHESIS & CATALYSIS,2018,360(13):2470-2475.
APA Chen, Weijie.,Liu, Fu-Xiaomin.,Gong, Wanchun.,Zhou, Zhi.,Gao, Hui.,...&Yi, Wei.(2018).Hydroxyl Group-Prompted and Iridium(III)-Catalyzed Regioselective C-H Annulation of N-phenoxyacetamides with Propargyl Alcohols.ADVANCED SYNTHESIS & CATALYSIS,360(13),2470-2475.
MLA Chen, Weijie,et al."Hydroxyl Group-Prompted and Iridium(III)-Catalyzed Regioselective C-H Annulation of N-phenoxyacetamides with Propargyl Alcohols".ADVANCED SYNTHESIS & CATALYSIS 360.13(2018):2470-2475.

入库方式： OAI收割

来源：上海药物研究所

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