Comparison of cytotoxicity induced by PM2.5-bound polycyclic aromatic compounds from different environments in Xi'an, China
文献类型：期刊论文
| 作者 | Niu, Xinyi1,6; Ho, Kin Fai6; Chuang, Hsiao-Chi5; Sun, Jian4; Huang, Yu1,3; Hu, Tafeng1,3; Xu, Hongmei2; Duan, Jing1,3; Lui, Ka Hei6; Cao, Junji1,3 |
| 刊名 | ATMOSPHERIC ENVIRONMENT
 |
| 出版日期 | 2019-11-01 |
| 卷号 | 216页码:8 |
| 关键词 | PM2.5 PAHs Bioreactivity Lung function |
| ISSN号 | 1352-2310 |
| DOI | 10.1016/j.atmosenv.2019.116929 |
| 通讯作者 | Ho, Kin Fai(kfho@cuhk.edu.hk) ; Cao, Junji(cao@loess.llqg.ac.cn) |
| 英文摘要 | The chemical and bioreactivity properties of fine particulate matter (PM2.5) in indoor and outdoor environments in Xi'an were characterized, and the lung function of various participants was investigated. The concentrations of polycyclic aromatic hydrocarbons (PAHs), oxygenated polycyclic aromatic hydrocarbons, and nitrated polycyclic aromatic hydrocarbons were higher in outdoor environments than in indoor environments; in addition, urban areas had higher concentrations of these compounds than did suburban areas, with fossil fuel combustion likely being the primary source. Moreover, PM2.5-induced inflammation was higher in urban areas than in suburban areas. Indoor environments with coal combustion emissions showed relatively higher oxidative potential and inflammation. Moderate (phenanthrene) to strong (acenaphthylene and benzo(a)pyrene) correlations were observed between selected PAHs against interleukin 6 (IL-6), 8-hydroxy-desoxyguanosine (8-OHdG), and necrosis factor-alpha (TNF-alpha). Moreover, 9-fluorenone, 9,10-anthraquinone, and 5,12-naphthacenequinone exhibited higher oxidative stress and inflammation than did their parent PAHs. Forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) were negatively correlated with 8-OHdG, and FEV1/FVC was negatively correlated with TNF-alpha and IL-6. These findings-which integrates PM2.5 with lung function and bioreactivity analyses-suggest that coal burning, especially indoors, could elevate the cytotoxicity of PM2.5 to the occupants and that chronic exposure may lead to a decline in lung function. |
| WOS关键词 | PARTICULATE MATTER PM2.5 ; HOUSEHOLD COAL COMBUSTION ; LUNG-CELLS L132 ; AIR-POLLUTION ; HYDROCARBONS PAHS ; OXYGENATED-PAHS ; CHEMICAL-COMPOSITION ; SOURCE APPORTIONMENT ; OXIDATIVE STRESS ; OUTDOOR AIR |
| 资助项目 | Research Grants Council of the Hong Kong Special Administrative Region China ; CUHK[14212116] ; Ministry of Science and Technology of China[2013FY112700] ; National Program on Basic Research Project of China[2013FY112500] |
| WOS研究方向 | Environmental Sciences & Ecology ; Meteorology & Atmospheric Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000525864200018 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 资助机构 | Research Grants Council of the Hong Kong Special Administrative Region China ; CUHK ; Ministry of Science and Technology of China ; National Program on Basic Research Project of China |
| 源URL | [http://ir.ieecas.cn/handle/361006/12559]  |
| 专题 | 地球环境研究所_粉尘与环境研究室 |
| 通讯作者 | Ho, Kin Fai; Cao, Junji |
| 作者单位 | 1.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol Chem & Phys, Xian, Peoples R China 2.Xi An Jiao Tong Univ, Dept Environm Sci & Engn, Xian, Peoples R China 3.Chinese Acad Sci, Inst Earth Environm, SKLLQG, Xian, Peoples R China 4.Xi An Jiao Tong Univ, Sch Human Settlements & Civil Engn, Xian, Peoples R China 5.Taipei Med Univ, Coll Med, Sch Resp Therapy, Taipei, Taiwan 6.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Niu, Xinyi,Ho, Kin Fai,Chuang, Hsiao-Chi,et al. Comparison of cytotoxicity induced by PM2.5-bound polycyclic aromatic compounds from different environments in Xi'an, China[J]. ATMOSPHERIC ENVIRONMENT,2019,216:8. |
| APA | Niu, Xinyi.,Ho, Kin Fai.,Chuang, Hsiao-Chi.,Sun, Jian.,Huang, Yu.,...&Cao, Junji.(2019).Comparison of cytotoxicity induced by PM2.5-bound polycyclic aromatic compounds from different environments in Xi'an, China.ATMOSPHERIC ENVIRONMENT,216,8. |
| MLA | Niu, Xinyi,et al."Comparison of cytotoxicity induced by PM2.5-bound polycyclic aromatic compounds from different environments in Xi'an, China".ATMOSPHERIC ENVIRONMENT 216(2019):8. |
入库方式： OAI收割
来源：地球环境研究所
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