Synthesis of Highly Fused Pyrano[2,3-b]pyridines via Rh(III)- Catalyzed C-H Activation and Intramolecular Cascade Annulation under Room Temperature
文献类型：期刊论文
| 作者 | Han, Xu1,2,3; Gao, Feng1,2; Li, Chunpu1,2,3; Fang, Daqing1,2,4; Xie, Xiong1,2,3; Zhou, Yu1,2,3 ; Liu, Hong1,2,3
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
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| 出版日期 | 2020-05-15 |
| 卷号 | 85期号:10页码:6281-6294 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.9b03102 |
| 通讯作者 | Zhou, Yu(zhouyu@simm.ac.cn) ; Liu, Hong(hliu@simm.ac.cn) |
| 英文摘要 | A facile access to the polycyclic-fused pyrano[2,3-b]pyridines has been established under room temperature via Rh(III)-catalyzed C-H bond activation and intramolecular cascade annulation. This strategy features high efficiency, unique versatility, and generality and it can occur under mild conditions in good to excellent yields. More importantly, this strategy can be extended to the late-stage functionalization of drugs possessing the CN group. |
| WOS关键词 | BOND ACTIVATION ; FUNCTIONALIZATION ; 1,2,4-TRIAZINES ; CONSTRUCTION ; HETEROCYCLES ; NITROGEN ; ACCESS |
| 资助项目 | National Natural Science Foundation of China[21672232] ; National Natural Science Foundation of China[21977106] ; National Natural Science Foundation of China[21702221] ; National Natural Science Foundation of China[81620108027] ; National S&T Major Projects[2018ZX09711002] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040217] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000535303300005 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/280010]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhou, Yu; Liu, Hong |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han, Xu,Gao, Feng,Li, Chunpu,et al. Synthesis of Highly Fused Pyrano[2,3-b]pyridines via Rh(III)- Catalyzed C-H Activation and Intramolecular Cascade Annulation under Room Temperature[J]. JOURNAL OF ORGANIC CHEMISTRY,2020,85(10):6281-6294. |
| APA | Han, Xu.,Gao, Feng.,Li, Chunpu.,Fang, Daqing.,Xie, Xiong.,...&Liu, Hong.(2020).Synthesis of Highly Fused Pyrano[2,3-b]pyridines via Rh(III)- Catalyzed C-H Activation and Intramolecular Cascade Annulation under Room Temperature.JOURNAL OF ORGANIC CHEMISTRY,85(10),6281-6294. |
| MLA | Han, Xu,et al."Synthesis of Highly Fused Pyrano[2,3-b]pyridines via Rh(III)- Catalyzed C-H Activation and Intramolecular Cascade Annulation under Room Temperature".JOURNAL OF ORGANIC CHEMISTRY 85.10(2020):6281-6294. |
入库方式： OAI收割
来源：上海药物研究所
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