Four undescribed sulfur-containing indole alkaloids with nitric oxide inhibitory activities from Isatis tinctoria L. roots
文献类型：期刊论文
| 作者 | Zhang, Dongdong1; Ruan, Deqing1; Li, Jingyi1; Chen, Zhaoqiang2; Zhu, Weiliang2 ; Guo, Fujiang1; Chen, Kaixian1,2; Li, Yiming1; Wang, Rui1
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2020-06-01 |
| 卷号 | 174页码:6 |
| 关键词 | Isatis tinctoria L. Brassicaceae Indole alkaloids Isatisindigoticanines H and I Isatindigosides F and G Nitric oxide inhibition |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2020.112337 |
| 通讯作者 | Li, Yiming(ymlius@163.com) ; Wang, Rui(wr@shutcm.edu.cn) |
| 英文摘要 | Four undescribed sulfur-containing indole alkaloids, isatisindigoticanines H, I and isatindigosides F, G along with three known analogues were obtained from Isatis tinctoria L. roots. Isatisindigoticanines H and I contained an unusual 1-(thiazol-4-yl)butane-1,2,3,4-tetraol moiety while isatindigosides F and G possessed a new 3- [3-(1H-indole-2-yeazet-2-yl]-1H-indole skeleton. The putative biosynthetic pathways of isatisindigoticanines H, I and isatindigosides F, G are proposed. The isolated compounds showed nitric oxide inhibitory effects with IC50 values ranging from 4.3 to 70.3 mu M. |
| WOS关键词 | GLYCOSIDES ; INDIGOTICA |
| 资助项目 | National Natural Science Foundation of China[81573571] ; National Natural Science Foundation of China[81673570] ; Excellent Academic Leaders Program of Shanghai[16XD1403500] ; programs of the High Level University Innovation Team ; Shanghai E-Research Institute of Bioactive Constituents in Traditional Chinese Medicine |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000529798600013 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/280548]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Yiming; Wang, Rui |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Dongdong,Ruan, Deqing,Li, Jingyi,et al. Four undescribed sulfur-containing indole alkaloids with nitric oxide inhibitory activities from Isatis tinctoria L. roots[J]. PHYTOCHEMISTRY,2020,174:6. |
| APA | Zhang, Dongdong.,Ruan, Deqing.,Li, Jingyi.,Chen, Zhaoqiang.,Zhu, Weiliang.,...&Wang, Rui.(2020).Four undescribed sulfur-containing indole alkaloids with nitric oxide inhibitory activities from Isatis tinctoria L. roots.PHYTOCHEMISTRY,174,6. |
| MLA | Zhang, Dongdong,et al."Four undescribed sulfur-containing indole alkaloids with nitric oxide inhibitory activities from Isatis tinctoria L. roots".PHYTOCHEMISTRY 174(2020):6. |
入库方式： OAI收割
来源：上海药物研究所
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