中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer's disease mice

文献类型：期刊论文

作者Zhang, Xiaochuan1,2; Yin, Xianzhen2; Zhang, Jingjing2; Li, Anan3,4; Gong, Hui3,4; Luo, Qingming3,4; Zhang, Haiyan2; Gao, Zhaobing2; Jiang, Hualiang1,2,5,6
刊名NATIONAL SCIENCE REVIEW
出版日期2019-11-01
卷号6期号:6页码:1223-1238
ISSN号2095-5138
关键词Micro-Optical Sectioning Tomography image optimization Alzheimer's disease impaired hippocampal vasculature virtual vascular endoscopy
DOI10.1093/nsr/nwz124
通讯作者Zhang, Haiyan(hzhang@simm.ac.cn) ; Gao, Zhaobing(zbgao@simm.ac.cn) ; Jiang, Hualiang(hljiang@simm.ac.cn)
英文摘要Accumulating evidence indicates the critical importance of cerebrovascular dysfunction in the pathogenesis of Alzheimer's disease (AD). However, systematic comparative studies on the precise brain vasculature of wild-type and AD model mice are still rare. Using an image-optimization method for analysing Micro-Optical Sectioning Tomography (MOST) data, we generated cross-scale whole-brain 3D atlases that cover the entire vascular system from large vessels down to smallest capillaries at submicron resolution, for both wild-type mice and a transgenic (APP/PS1) mouse model of AD. In addition to distinct vascular patterns in different brain regions, we found that the main vessels of the molecular layer of the hippocampal dentate gyms (DG-ml) undergo abrupt changes in both diameter and branch angle, spreading a unique comb-like pattern of capillaries. By using a quantitative analysis workflow, we identified in the hippo campus of AD mice an overall reduction of the mean vascular diameter, volume fraction and branch angle, with most significant impairment in the DG-ml. In addition, virtual endoscopy revealed irregular morphological features in the vessel lumen of the AD mice, potentially contributing to the impairment of blood flow. Our results demonstrate the capability of high-resolution cross-scale evaluation of brain vasculature and underscore the importance of studying hippocampal micro circulation for understanding AD pathogenesis.
WOS关键词MOUSE-BRAIN ; IN-VIVO ; COGNITIVE IMPAIRMENT ; TRANSGENIC MICE ; TOMOGRAPHY ; DENSITY ; MODEL ; ABNORMALITIES ; VISUALIZATION ; SEGMENTATION
资助项目Shanghai Municipal Science and Technology Major Project[2018SHZDZX05] ; National Science Fund for Distinguished Young Scholars[81825021] ; Youth Innovation Promotion Association CAS[2018323]
WOS研究方向Science & Technology - Other Topics
语种英语
出版者OXFORD UNIV PRESS
WOS记录号WOS:000512970300031
源URL[http://119.78.100.183/handle/2S10ELR8/281594]  
专题中国科学院上海药物研究所
通讯作者Zhang, Haiyan; Gao, Zhaobing; Jiang, Hualiang
作者单位1.East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
3.Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Britton Chance Ctr Biomed Photon, Wuhan 430074, Peoples R China
4.Huazhong Univ Sci & Technol, Sch Engn Sci, MoE Key Lab Biomed Photon, Wuhan 430074, Peoples R China
5.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 200031, Peoples R China
6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Xiaochuan,Yin, Xianzhen,Zhang, Jingjing,et al. High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer's disease mice[J]. NATIONAL SCIENCE REVIEW,2019,6(6):1223-1238.
APA Zhang, Xiaochuan.,Yin, Xianzhen.,Zhang, Jingjing.,Li, Anan.,Gong, Hui.,...&Jiang, Hualiang.(2019).High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer's disease mice.NATIONAL SCIENCE REVIEW,6(6),1223-1238.
MLA Zhang, Xiaochuan,et al."High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer's disease mice".NATIONAL SCIENCE REVIEW 6.6(2019):1223-1238.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。