Alkaloids with Nitric Oxide Inhibitory Activities from the Roots of Isatis tinctoria
文献类型：期刊论文
| 作者 | Zhang, Dongdong2; Shi, Yanhong3; Li, Jingyi2; Ruan, Deqing2; Jia, Qi2; Zhu, Weiliang1 ; Chen, Kaixian1,2; Li, Yiming2; Wang, Rui2
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| 刊名 | MOLECULES
 |
| 出版日期 | 2019-11-01 |
| 卷号 | 24期号:22页码:9 |
| 关键词 | Isatis tinctoria roots alkaloids structure identification anti-inflammatory activity |
| DOI | 10.3390/molecules24224033 |
| 通讯作者 | Li, Yiming(ymlius@163.com) ; Wang, Rui(wr@shutcm.edu.cn) |
| 英文摘要 | As our ongoing research project on Ban Lan Gen (Isatis tinctoria roots), a total of 23 alkaloids were obtained. Compounds 1 and 2 contain an unusual C-C bond between the 2(1H)-quinolinone moiety and the phenol moiety and between the 2(1H)-quinolinone moiety and the 1H-indole moiety, respectively. Compound 3 possesses an unusual carbon skeleton and its putative biosynthetic pathway was discussed, and Compound 23 was deduced as a new indole alkaloid glycoside. Compounds 4-7 were identified as four new natural products by extensive spectroscopic experiments. Additionally, the anti-inflammatory activity was assessed based on nitric oxide (NO) production using Lipopolysaccharide-stimulated RAW264.7 macrophages. Compounds 9, 15, and 17 showed inhibitory effects with IC50 values of 1.2, 5.0, and 74.4 mu M. |
| WOS关键词 | INDIGOTICA ; GLYCOSIDES |
| 资助项目 | National Natural Science Foundation of China[81573571] ; National Natural Science Foundation of China[81673570] ; Excellent Academic Leaders Program of Shanghai[16XD1403500] ; programs of the High Level University Innovation Team ; Shanghai E-Research Institute of Bioactive Constituents in Traditional Chinese Medicine ; Shanghai Scientific and Technological Innovation Program[18401931100] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000501529700022 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282051]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Yiming; Wang, Rui |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Inst TCM Int Standardizat, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Dongdong,Shi, Yanhong,Li, Jingyi,et al. Alkaloids with Nitric Oxide Inhibitory Activities from the Roots of Isatis tinctoria[J]. MOLECULES,2019,24(22):9. |
| APA | Zhang, Dongdong.,Shi, Yanhong.,Li, Jingyi.,Ruan, Deqing.,Jia, Qi.,...&Wang, Rui.(2019).Alkaloids with Nitric Oxide Inhibitory Activities from the Roots of Isatis tinctoria.MOLECULES,24(22),9. |
| MLA | Zhang, Dongdong,et al."Alkaloids with Nitric Oxide Inhibitory Activities from the Roots of Isatis tinctoria".MOLECULES 24.22(2019):9. |
入库方式： OAI收割
来源：上海药物研究所
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