Spiroalanpyrroids A and B, sesquiterpene alkaloids with a unique spiro-eudesmanolide-pyrrolizidine skeleton from Inula helenium
文献类型：期刊论文
| 作者 | Cai, You-Sheng4; Wu, Zi4; Zheng, Xiao-Qin4; Wang, Cong1,5; Wang, Jian-Rong3 ; Zhang, Xin-Xin4; Qiu, Guofu4; Zhu, Kongkai2; Cao, Shugeng5; Yu, Jianqing4
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| 刊名 | ORGANIC CHEMISTRY FRONTIERS
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| 出版日期 | 2020-01-21 |
| 卷号 | 7期号:2页码:303-309 |
| ISSN号 | 2052-4129 |
| DOI | 10.1039/c9qo01248f |
| 通讯作者 | Yu, Jianqing(jqyu@whu.edu.cn) |
| 英文摘要 | Spiroalanpyrroids A (1) and B (2), two sesquiterpene alkaloids with an unprecedented eudesmanolide-pyrrolizidine spiro[5.5] framework, were isolated together with two new sesquiterpene-amino acid adducts, helenalanprolines A (3) and B (4), from the roots of Inula helenium. Their structures were elucidated by spectroscopic data analysis, ECD calculations, and single-crystal X-ray diffraction analysis. A plausible biosynthetic pathway was proposed for 1 and 2. Bioassays showed that compounds 3 and 4 significantly inhibited nitric oxide production in lipopolysaccharide-induced RAW264.7 macrophages with IC50 values of 15.8 and 13.5 mu M, respectively. |
| WOS关键词 | LACTONES ; METABOLITES |
| 资助项目 | National Natural Science Foundation of China[31670348] ; National Natural Science Foundation of China[31970369] ; National Natural Science Foundation of China[81973201] ; National Key R&D Program of China[2018YFC0311002] ; Fundamental Research Funds for the Central Universities[2042019kf0228] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000508568000008 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282433]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yu, Jianqing |
| 作者单位 | 1.Guangxi Univ Nationalities, Sch Chem & Chem Engn, Guangxi Key Lab Chem & Engn Forest Prod, Nanning 530006, Peoples R China 2.Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China 4.Wuhan Univ, Sch Pharmaceut Sci, Inst TCM & Nat Prod, Wuhan 430071, Peoples R China 5.Univ Hawaii, Daniel K Inouye Coll Pharm, Dept Pharmaceut Sci, Hilo, HI 96720 USA |
| 推荐引用方式 GB/T 7714 | Cai, You-Sheng,Wu, Zi,Zheng, Xiao-Qin,et al. Spiroalanpyrroids A and B, sesquiterpene alkaloids with a unique spiro-eudesmanolide-pyrrolizidine skeleton from Inula helenium[J]. ORGANIC CHEMISTRY FRONTIERS,2020,7(2):303-309. |
| APA | Cai, You-Sheng.,Wu, Zi.,Zheng, Xiao-Qin.,Wang, Cong.,Wang, Jian-Rong.,...&Yu, Jianqing.(2020).Spiroalanpyrroids A and B, sesquiterpene alkaloids with a unique spiro-eudesmanolide-pyrrolizidine skeleton from Inula helenium.ORGANIC CHEMISTRY FRONTIERS,7(2),303-309. |
| MLA | Cai, You-Sheng,et al."Spiroalanpyrroids A and B, sesquiterpene alkaloids with a unique spiro-eudesmanolide-pyrrolizidine skeleton from Inula helenium".ORGANIC CHEMISTRY FRONTIERS 7.2(2020):303-309. |
入库方式： OAI收割
来源：上海药物研究所
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