Improved synthesis of YG-056SP, a potent oxazolidinone antibacterial candidate against multi-drug resistant bacteria
文献类型：期刊论文
| 作者 | Chen, Peng1; Zhang, Yinyong2; Shi, Chenghui2; Meng, Xin2; Yang, Yushe2 ; Zhou, Xianli1; Guo, Bin2
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| 刊名 | JOURNAL OF CHEMICAL RESEARCH
 |
| 出版日期 | 2019-09-01 |
| 卷号 | 43期号:9-10页码:380-385 |
| 关键词 | chiral separation Gram-positive bacteria oxazolidinone practical synthesis YG-056SP |
| ISSN号 | 1747-5198 |
| DOI | 10.1177/1747519819868198 |
| 通讯作者 | Guo, Bin(guobin@simm.ac.cn) |
| 英文摘要 | An improved process for the synthesis of YG-056SP, a potent oxazolidinone candidate against multi-drug resistant bacteria, is developed. Compared with the original synthetic route, this new approach is two steps shorter, and all of the steps involve simple purifications without column chromatography. More importantly, it avoids the use of explosive azide compounds and expensive metal catalysts. The new reaction conditions are mild and safe, which is more suitable for the scalable synthesis of YG-056SP for preclinical studies. |
| WOS关键词 | ANTIBIOTICS ; INFECTIONS |
| 资助项目 | Youth Innovation Promotion Association of the Chinese Academy of Sciences[2016262] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000490982700010 |
| 出版者 | SAGE PUBLICATIONS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282580]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Guo, Bin |
| 作者单位 | 1.Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu, Sichuan, Peoples R China 2.Univ Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Peng,Zhang, Yinyong,Shi, Chenghui,et al. Improved synthesis of YG-056SP, a potent oxazolidinone antibacterial candidate against multi-drug resistant bacteria[J]. JOURNAL OF CHEMICAL RESEARCH,2019,43(9-10):380-385. |
| APA | Chen, Peng.,Zhang, Yinyong.,Shi, Chenghui.,Meng, Xin.,Yang, Yushe.,...&Guo, Bin.(2019).Improved synthesis of YG-056SP, a potent oxazolidinone antibacterial candidate against multi-drug resistant bacteria.JOURNAL OF CHEMICAL RESEARCH,43(9-10),380-385. |
| MLA | Chen, Peng,et al."Improved synthesis of YG-056SP, a potent oxazolidinone antibacterial candidate against multi-drug resistant bacteria".JOURNAL OF CHEMICAL RESEARCH 43.9-10(2019):380-385. |
入库方式： OAI收割
来源：上海药物研究所
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