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Alkaloid Enantiomers from the Roots of Isatis indigotica

文献类型：期刊论文

作者Zhang, Dongdong3; Shi, Yanhong1; Xu, Rui3; Du, Kang3; Guo, Fujiang3; Chen, Kaixian2,3; Li, Yiming3; Wang, Rui3
刊名MOLECULES
出版日期2019-09-01
卷号24期号:17页码:8
关键词Isatis indigotica alkaloid enantiomers structure deduction anti-inflammatory activity
DOI10.3390/molecules24173140
通讯作者Li, Yiming(ymlius@163.com) ; Wang, Rui(wr@shutcm.edu.cn)
英文摘要Five pairs of alkaloid enantiomers (1a/1b-5a/5b) were obtained from Isatis indigotica (I. indigotica) roots. Amongthem, 1a/1b, 2a/2b and 3a/3b were determined as three pairs of new alkaloid enantiomers. Their structures were elucidated by physicochemical properties and spectroscopic methods. The absolute configurations were deduced by comparison of their experimental circular dichroism (CD) and calculated electronic circular dichroism (ECD) spectra, as well as by single-crystal X-ray crystallography using anomalous scattering of Cu K alpha radiation. Alkaloids 1a and 1b possess an unpresented carbon skeleton and their putative biosynthetic pathways are discussed. Moreover, all of the alkaloids were tested for their nitric oxide (NO) inhibitory effects in RAW 264.7 cells, and 4a and 4b showed inhibitory effects with IC50 values of 76.97 mu M and 65.88 mu M, respectively.
WOS关键词GLYCOSIDES
资助项目National Natural Science Foundation of China[81573571] ; National Natural Science Foundation of China[81673570] ; Excellent Academic Leaders Program of Shanghai[16XD1403500] ; programs of the High Level University Innovation Team ; Shanghai E-Research Institute of Bioactive Constituents in Traditional Chinese Medicine ; Shanghai Scientific and Technological Innovation Program[18401931100]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000488613700120
出版者MDPI
源URL[http://119.78.100.183/handle/2S10ELR8/282639]  
专题中国科学院上海药物研究所
通讯作者Li, Yiming; Wang, Rui
作者单位1.Shanghai Univ Tradit Chinese Med, Inst TCM Int Standardizat, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Dongdong,Shi, Yanhong,Xu, Rui,et al. Alkaloid Enantiomers from the Roots of Isatis indigotica[J]. MOLECULES,2019,24(17):8.
APA Zhang, Dongdong.,Shi, Yanhong.,Xu, Rui.,Du, Kang.,Guo, Fujiang.,...&Wang, Rui.(2019).Alkaloid Enantiomers from the Roots of Isatis indigotica.MOLECULES,24(17),8.
MLA Zhang, Dongdong,et al."Alkaloid Enantiomers from the Roots of Isatis indigotica".MOLECULES 24.17(2019):8.

入库方式： OAI收割

来源：上海药物研究所

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