A comprehensive study of pomegranate flowers polyphenols and metabolites in rat biological samples by high-performance liquid chromatography quadrupole time-of-flight mass spectrometry
文献类型：期刊论文
| 作者 | Yisimayili, Zainaipuguli1,2,3; Abdulla, Rahima1; Tian, Qiang2; Wang, Yangyang2,3; Chen, Mingcang2; Sun, Zhaolin2; Li, Zhixiong2 ; Liu, Fang2; Aisa, Haji Akber1,3; Huang, Chenggang2,3
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| 刊名 | JOURNAL OF CHROMATOGRAPHY A
 |
| 出版日期 | 2019-10-25 |
| 卷号 | 1604页码:13 |
| ISSN号 | 0021-9673 |
| 关键词 | Punica granatum L. flowers Polyphenols Ellagitannin Metabolism HPLC-Q-TOF-MS2 |
| DOI | 10.1016/j.chroma.2019.460472 |
| 通讯作者 | Aisa, Haji Akber(haji@ms.xjb.ac.cn) ; Huang, Chenggang(cghsimm@126.com) |
| 英文摘要 | Pomegranate flowers is an ancient medicine that has commonly been used to treat various diseases such as diabetes. However, no reports are available on the metabolic profile of pomegranate flowers in vivo. In the present study, with the aid of HPLC-Q-TOF-MS2, 67 compounds were identified in pomegranate flowers extract, including 18 ellagitannins, 14 gallic acid and galloyl derivatives, five anthocyanins and 18 flavonoids. Seven compounds were firstly identified. In vivo, 22 absorbed compounds and 35 metabolites were identified in rat biosamples (urine, feces, plasma and tissues) after orally administered with pomegranate flowers extract. This result showed that not all compounds abundant in pomegranate flowers extract could be absorbed well in plasma and tissues. This finding also suggested a potential correlation between study on metabolic profile of these compounds in vivo and study on strategy of screening bioactivity of the isolates with in vitro cell systems evaluation. Notably, mono-glucuronide conjugated metabolite of ellagitannin compound (corilagin) was firstly identified. In addition, this is first report to identify phase II conjugate metabolites of ellagitannins in vivo after oral administration of ellagitanninsrich extracts (or foods). Thus, characterizing its multiple constitution, absorption and metabolic fate of these compounds in vivo is helpful to better analyze the active components in pomegranate flowers. (C) 2019 The Authors. Published by Elsevier B.V. |
| WOS关键词 | PUNICA-GRANATUM ; PHENOLIC-COMPOUNDS ; ALPHA-GLUCOSIDASE ; ELLAGITANNINS ; EXTRACT ; QUANTIFICATION ; IDENTIFICATION ; ANTHOCYANINS ; ACID |
| 资助项目 | Science and Technology Service Network Initiative of the Chinese Academy of Sciences[KFJ-STS-QYZD-066] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000488303200011 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282663]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Aisa, Haji Akber; Huang, Chenggang |
| 作者单位 | 1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yisimayili, Zainaipuguli,Abdulla, Rahima,Tian, Qiang,et al. A comprehensive study of pomegranate flowers polyphenols and metabolites in rat biological samples by high-performance liquid chromatography quadrupole time-of-flight mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY A,2019,1604:13. |
| APA | Yisimayili, Zainaipuguli.,Abdulla, Rahima.,Tian, Qiang.,Wang, Yangyang.,Chen, Mingcang.,...&Huang, Chenggang.(2019).A comprehensive study of pomegranate flowers polyphenols and metabolites in rat biological samples by high-performance liquid chromatography quadrupole time-of-flight mass spectrometry.JOURNAL OF CHROMATOGRAPHY A,1604,13. |
| MLA | Yisimayili, Zainaipuguli,et al."A comprehensive study of pomegranate flowers polyphenols and metabolites in rat biological samples by high-performance liquid chromatography quadrupole time-of-flight mass spectrometry".JOURNAL OF CHROMATOGRAPHY A 1604(2019):13. |
入库方式： OAI收割
来源：上海药物研究所
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