troglitazoneinhibitscellproliferationbyattenuationofepidermalgrowthfactorreceptorsignalingindependentofperoxisomeproliferatoractivatedreceptor
文献类型：期刊论文
| 作者 | Xiaoqi Li2; Xuanming Yang2; Youli Xu2; Xuejun Jiang3; Xin Li1; Fajun Nan1 ; Hong Tang2
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| 刊名 | cellresearch
 |
| 出版日期 | 2009 |
| 卷号 | 000期号:006页码:720 |
| 关键词 | 表皮生长因子受体 过氧化物酶体 细胞增殖 信号调节 曲格列酮 活化 蛋白磷酸化 EGFR |
| ISSN号 | 1001-0602 |
| 英文摘要 | Peroxisome proliferator-activated receptors （PPAR） belong to the nuclear hormone receptor superfamily of ligand-dependent transcription factors. Recent results have shown that agonists of PPARy, such as troglitazone （TGZ）, can inhibit cell proliferation and promote cell differentiation independent of PPARy. In the present study, we provide evidence that TGZ may bind directly to EGFR and trigger its signaling and internalization independent of PPARγ. Detailed studies revealed that prolonged incubation with TGZ effectively attenuated EGFR signaling by targeting the receptor to the endo-lysosomal degradation machinery. Although the extracellular signal-regulated kinasesignaling pathway was transiently activated by TGZ in EGFR overexpressing cancer cells, inhibition of EGF-induced Akt phosphorylation most likely accounted for the growth arrest of tumor cells caused by TGZ at pharmacologically achievable concentrations. Therefore, we have provided a new line of evidence indicating that TGZ inhibits cell pro- liferation by promoting EGFR degradation and attenuating Akt phosphorylation. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/286956]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.中国科学院生物物理研究所 3.中国科学院微生物研究所 |
| 推荐引用方式 GB/T 7714 | Xiaoqi Li,Xuanming Yang,Youli Xu,et al. troglitazoneinhibitscellproliferationbyattenuationofepidermalgrowthfactorreceptorsignalingindependentofperoxisomeproliferatoractivatedreceptor[J]. cellresearch,2009,000(006):720. |
| APA | Xiaoqi Li.,Xuanming Yang.,Youli Xu.,Xuejun Jiang.,Xin Li.,...&Hong Tang.(2009).troglitazoneinhibitscellproliferationbyattenuationofepidermalgrowthfactorreceptorsignalingindependentofperoxisomeproliferatoractivatedreceptor.cellresearch,000(006),720. |
| MLA | Xiaoqi Li,et al."troglitazoneinhibitscellproliferationbyattenuationofepidermalgrowthfactorreceptorsignalingindependentofperoxisomeproliferatoractivatedreceptor".cellresearch 000.006(2009):720. |
入库方式： OAI收割
来源：上海药物研究所
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