advancesinhiv1integraseinhibitorsdirectedtowarddifferentstepsofintegration
文献类型：期刊论文
| 作者 | Ceng LF(曾立凡); Long YQ(龙亚秋) |
| 刊名 | chinesejournaloforganicchemistry
 |
| 出版日期 | 2009 |
| 卷号 | 29期号:4页码:536 |
| 关键词 | IMMUNODEFICIENCY-VIRUS TYPE-1 ACTIVE ANTIRETROVIRAL THERAPY HIGHLY EFFICIENT PREPARATION STYRYLQUINOLINE DERIVATIVES REVERSE-TRANSCRIPTASE PEPTIDE INHIBITORS VIRAL REPLICATION DESIGN MECHANISM BINDING HIV-1 integrase inhibitor anti-HIV drug raltegravir (MK-0518) GS-9137 |
| ISSN号 | 0253-2786 |
| 英文摘要 | Based on the mode of action, the present paper reviews the HIV-1 integrase inhibitors reported recently with respect to the structure features, pharmacophore analysis, chemical synthesis and the development status, according to the categories of strand transfer inhibitor, IN-DNA interaction inhibitor, 3'-processing inhibitor, non-specific inhibitor and peptide inhibitor, respectively. The strand transfer inhibitor is the most developed class of HIV-1 integrase inhibitors, among which MK-0518 was the first FDA-approved HIV-1 integrase inhibitor as anti-HIV drug. HIV-1 integrase inhibitor has enriched the highly active antiretroviral therapy (HAART) regimen and provides an efficient treatment for multiple drug-resistant patients. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/287274]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Ceng LF,Long YQ. advancesinhiv1integraseinhibitorsdirectedtowarddifferentstepsofintegration[J]. chinesejournaloforganicchemistry,2009,29(4):536. |
| APA | 曾立凡,&龙亚秋.(2009).advancesinhiv1integraseinhibitorsdirectedtowarddifferentstepsofintegration.chinesejournaloforganicchemistry,29(4),536. |
| MLA | 曾立凡,et al."advancesinhiv1integraseinhibitorsdirectedtowarddifferentstepsofintegration".chinesejournaloforganicchemistry 29.4(2009):536. |
入库方式： OAI收割
来源：上海药物研究所
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