Lignans from Isatis indigotica roots and their inhibitory effects on nitric oxide production
文献类型：期刊论文
| 作者 | Zhang, Dongdong2; Li, Jingyi2; Ruan, Deqing2; Chen, Zhaoqiang1; Zhu, Weiliang1 ; Shi, Yanhong3; Chen, Kaixian1,2; Li, Yiming2; Wang, Rui2
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2019-09-01 |
| 卷号 | 137页码:6 |
| 关键词 | Isatis indigotica Lignans Structure determination Anti-inflammatory activity Nitric oxide production |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2019.104189 |
| 通讯作者 | Li, Yiming(ymlius@163.com) ; Wang, Rui(wr@shutcm.edu.cn) |
| 英文摘要 | Seventeen lignans (1-17) were obtained from the roots of Isatis indigotica (I. indigotica). Among them, isatindigosesquilignans A-C (1-3) were deduced as three undescribed sesquilignans, which possess unusual carbon skeleton of aryltetralin unit connected with a C6-C3 moiety via a five-membered ring of C-3-C-8 ''-C-7 ''-O-C-4. Isatindigosesquilignans B and C were determined as the first examples of its glycosides from a natural source and a plausible biosynthetic pathway was proposed. Moreover, all of the isolated lignans were assayed regarding their inhibitory effects on nitric oxide (NO) production in RAW 264.7 cells and compounds 1, 2 and 7 showed inhibitory effects with IC50 values ranging from 19.46 mu M to 64.82 mu M. |
| WOS关键词 | STEROIDAL GLYCOSIDES ; BIOACTIVE PHENOLICS ; ALKALOIDS ; CONSTITUENTS ; LEAVES ; FRUITS |
| 资助项目 | National Natural Science Foundation of China[81573571] ; National Natural Science Foundation of China[81673570] ; Excellent Academic Leaders Program of Shanghai[16XD1403500] ; Shanghai Scientific and Technological Innovation Program[18401931100] ; High level University Innovation Team ; Shanghai E-Research Institute of Bioactive Constituents in Traditional Chinese Medicine |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000484878400005 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/288752]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Yiming; Wang, Rui |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Inst TCM Int Standardizat, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Dongdong,Li, Jingyi,Ruan, Deqing,et al. Lignans from Isatis indigotica roots and their inhibitory effects on nitric oxide production[J]. FITOTERAPIA,2019,137:6. |
| APA | Zhang, Dongdong.,Li, Jingyi.,Ruan, Deqing.,Chen, Zhaoqiang.,Zhu, Weiliang.,...&Wang, Rui.(2019).Lignans from Isatis indigotica roots and their inhibitory effects on nitric oxide production.FITOTERAPIA,137,6. |
| MLA | Zhang, Dongdong,et al."Lignans from Isatis indigotica roots and their inhibitory effects on nitric oxide production".FITOTERAPIA 137(2019):6. |
入库方式： OAI收割
来源：上海药物研究所
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