Isatisindigoticanine A, a novel indole alkaloid with an unpresented carbon skeleton from the roots of Isatis tinctoria
文献类型：期刊论文
| 作者 | Zhang, Dongdong1; Shi, Yanhong2; Shi, Songshan3; Wu, Ximin1; Zhang, Liudiang1; Chen, Kaixian1,4 ; Li, Yiming1; Wang, Rui1
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| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 出版日期 | 2019-07-19 |
| 页码 | 7 |
| 关键词 | Anti-inflammatory activity indole alkaloid Isatis tinctoria isatisindigoticanine A |
| ISSN号 | 1478-6419 |
| DOI | 10.1080/14786419.2019.1644632 |
| 通讯作者 | Li, Yiming(ymlius@163.com) ; Wang, Rui(wr@shutcm.edu.cn) |
| 英文摘要 | Isatisindigoticanine A (1), a new indole alkaloid with an unusual carbon skeleton of a benzofuran-3-one unit connected with a 1H-indole-3-yl unit and a 4-(1,2-dihydroxyethyl)-6-oxa-3-azabicyclo[3.1.0]hexan-2-one unit via a C-3C-8'' bond and a C-4'C-8'' bond, was obtained from the roots of Isatis tinctoria. Its structure was determined by physicochemical properties and spectroscopic methods including 1 D, 2 D NMR, IR, HRESIMS data. The absolutely configurations were deduced by comparison of its experimental CD and calculated ECD spectra. Nitric oxide (NO) inhibitory activities of isatisindigoticanine A was also evaluated in the LPS-stimulated RAW 264.7 cells, however, no inhibitory effect was presented. |
| WOS关键词 | GLYCOSIDES ; INDIGOTICA |
| 资助项目 | National Natural Science Foundation of China[81573571] ; National Natural Science Foundation of China[81673570] ; Excellent Academic Leaders Program of Shanghai[16XD1403500] ; Shanghai Scientific and Technological Innovation Program[18401931100] ; program of High level University Innovation Team ; program of Shanghai E-Research Institute of Bioactive Constituents in Traditional Chinese Medicine |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000477210500001 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/289070]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Yiming; Wang, Rui |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R China 2.Univ Tradit Chinese Med, Inst TCM Int Standardizat Shanghai, Shanghai, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Shanghai, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Dongdong,Shi, Yanhong,Shi, Songshan,et al. Isatisindigoticanine A, a novel indole alkaloid with an unpresented carbon skeleton from the roots of Isatis tinctoria[J]. NATURAL PRODUCT RESEARCH,2019:7. |
| APA | Zhang, Dongdong.,Shi, Yanhong.,Shi, Songshan.,Wu, Ximin.,Zhang, Liudiang.,...&Wang, Rui.(2019).Isatisindigoticanine A, a novel indole alkaloid with an unpresented carbon skeleton from the roots of Isatis tinctoria.NATURAL PRODUCT RESEARCH,7. |
| MLA | Zhang, Dongdong,et al."Isatisindigoticanine A, a novel indole alkaloid with an unpresented carbon skeleton from the roots of Isatis tinctoria".NATURAL PRODUCT RESEARCH (2019):7. |
入库方式： OAI收割
来源：上海药物研究所
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