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Cp*Rh(III)-Catalyzed C-H Bond Difluorovinylation of Indoles with alpha,alpha-Difluorovinyl Tosylate

文献类型：期刊论文

作者Yang, Lisheng1,2,3; Li, Chunpu2,3; Wang, Dechuan1; Liu, Hong2,3
刊名JOURNAL OF ORGANIC CHEMISTRY
出版日期2019-06-07
卷号84期号:11页码:7320-7330
ISSN号0022-3263
DOI10.1021/acs.joc.9b00957
通讯作者Wang, Dechuan(wdc@cpu.edu.cn) ; Liu, Hong(hliu@simm.ac.cn)
英文摘要Unprecedented Rh(III)-catalyzed C-H bond difluorovinylation of indoles has been successfully developed, and this method provided an example of direct difluorovinylation reaction through C-H bond activation which was rarely reported. In this context, N-ethoxycarbamoyl served as the directing group and 2,2-difluorovinyl tosylates were used for the construction of difluorovinyl-substituted indoles. This method provided a practical strategy for difluorovinylation of indoles with moderate to good yields and is characterized by the broad synthetic utility, mild conditions, and high efficiency.
WOS关键词GEM-DIFLUOROALKENES ; PROPARGYL ALCOHOLS ; CARBONYL-COMPOUNDS ; FLUORINE ; INHIBITORS ; PHARMACEUTICALS ; ACTIVATION ; ANNULATION ; BENZAMIDES ; POTENT
资助项目National Natural Science Foundation of China[81620108027] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[91229204] ; National Natural Science Foundation of China[81220108025] ; National Natural Science Foundation of China[81602975] ; Major Project of Chinese National Programs for Fundamental Research and Development[2015CB910304] ; National S&T Major Projects[2014ZX09507002-001] ; National S&T Major Projects[2015ZX09103003]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000471212000071
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/289546]  
专题新药研究国家重点实验室
通讯作者Wang, Dechuan; Liu, Hong
作者单位1.China Pharmaceut Univ, Sch Sci, 639 Longmian Ave, Nanjing 211198, Jiangsu, Peoples R China
2.Chinese Acad Sci, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Lisheng,Li, Chunpu,Wang, Dechuan,et al. Cp*Rh(III)-Catalyzed C-H Bond Difluorovinylation of Indoles with alpha,alpha-Difluorovinyl Tosylate[J]. JOURNAL OF ORGANIC CHEMISTRY,2019,84(11):7320-7330.
APA Yang, Lisheng,Li, Chunpu,Wang, Dechuan,&Liu, Hong.(2019).Cp*Rh(III)-Catalyzed C-H Bond Difluorovinylation of Indoles with alpha,alpha-Difluorovinyl Tosylate.JOURNAL OF ORGANIC CHEMISTRY,84(11),7320-7330.
MLA Yang, Lisheng,et al."Cp*Rh(III)-Catalyzed C-H Bond Difluorovinylation of Indoles with alpha,alpha-Difluorovinyl Tosylate".JOURNAL OF ORGANIC CHEMISTRY 84.11(2019):7320-7330.

入库方式： OAI收割

来源：上海药物研究所

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