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Industry-Oriented Route Evaluation and Process Optimization for the Preparation of Brexpiprazole

文献类型：期刊论文

作者Chen, Weiming1,2; Suo, Jin3; Liu, Yongjian4; Xie, Yuanchao3; Wu, Mingjun4; Zhu, Fuqiang4; Nian, Yifeng4; Aisa, Haji A.1; Shen, Jingshan3
刊名ORGANIC PROCESS RESEARCH & DEVELOPMENT
出版日期2019-05-01
卷号23期号:5页码:852-857
关键词brexpiprazole route evaluation process optimization impurity control strategy
ISSN号1083-6160
DOI10.1021/acs.oprd.8b00438
通讯作者Aisa, Haji A.(haji@ms.xjb.ac.cn) ; Shen, Jingshan(shenjingshan@simm.ac.cn)
英文摘要Efforts toward route evaluation and process optimization for the preparation of brexpiprazole (1) are described. Starting from commercially available dihydroquinolinone 11, a three-step synthesis route composed of O-alkylation, oxidation, and N-alkylation was selected for industry-oriented process development aiming to reduce side reactions and achieve better impurity profiles. The reaction conditions of the three steps were investigated, and the control strategy for the process-related impurities was established. The optimized process was validated on the kilogram scale and now is viable for commercialization, with the results of not less than 99.90% purity of 1 (by HPLC) and not more than 0.05% of persistent impurities 15 and 16.
WOS关键词2,3-DICHLORO-5,6-DICYANOBENZOQUINONE
资助项目National Science Foundation for Young Scientists of China[21502209]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000468697300017
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/289763]  
专题中国科学院上海药物研究所
通讯作者Aisa, Haji A.; Shen, Jingshan
作者单位1.Chinese Acad Sci, Key Lab Plant Resources & Chem Arid Reg, Xinjiang Tech Inst Phys & Chem, South Beijing Rd 40-1, Urumqi 830011, Xinjiang, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Chinese Acad Sci, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
4.Topharman Shanghai Co Ltd, Bldg 1,388 Jialilue Rd,Zhangjiang Hitech Pk, Shanghai 201209, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Weiming,Suo, Jin,Liu, Yongjian,et al. Industry-Oriented Route Evaluation and Process Optimization for the Preparation of Brexpiprazole[J]. ORGANIC PROCESS RESEARCH & DEVELOPMENT,2019,23(5):852-857.
APA Chen, Weiming.,Suo, Jin.,Liu, Yongjian.,Xie, Yuanchao.,Wu, Mingjun.,...&Shen, Jingshan.(2019).Industry-Oriented Route Evaluation and Process Optimization for the Preparation of Brexpiprazole.ORGANIC PROCESS RESEARCH & DEVELOPMENT,23(5),852-857.
MLA Chen, Weiming,et al."Industry-Oriented Route Evaluation and Process Optimization for the Preparation of Brexpiprazole".ORGANIC PROCESS RESEARCH & DEVELOPMENT 23.5(2019):852-857.

入库方式： OAI收割

来源：上海药物研究所

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