Indoor, outdoor, and personal exposure to PM2.5 and their bioreactivity among healthy residents of Hong Kong
文献类型：期刊论文
| 作者 | Chen, Xiao-Cui1,10,11; Chuang, Hsiao-Chi2; Ward, Tony J.3; Tian, Linwei4; Cao, Jun-Ji5,6; Ho, Steven Sai-Hang12,13; Lau, Ngar-Cheung1,7; Hsiao, Ta-Chih9; Yim, Steve H. L.1,7; Ho, Kin-Fai1,8 |
| 刊名 | ENVIRONMENTAL RESEARCH
 |
| 出版日期 | 2020-09-01 |
| 卷号 | 188页码:13 |
| 关键词 | Organic carbon PAHs Inflammation Oxidative stress Biomarkers |
| ISSN号 | 0013-9351 |
| DOI | 10.1016/j.envres.2020.109780 |
| 通讯作者 | Ho, Kin-Fai(kfho@cuhk.edu.hk) |
| 英文摘要 | Direct evidence about associations between fine particles (PM2.5) components and the corresponding PM2.5 bioreactivity at the individual level is limited. We conducted a panel study with repeated personal measurements involving 56 healthy residents in Hong Kong. Fractional exhaled nitric oxide (FeNO) levels were measured from these subjects. Out of 56 subjects, 27 (48.2%) participated in concurrent outdoor, indoor, and personal PM2.5 monitoring. Organic carbon (OC), elemental carbon (EC), particle bound-polycyclic aromatic hydrocarbons (PAHs), and phthalates were analyzed. Alteration in cell viability, lactic dehydrogenase (LDH), interleukin-6 (IL-6), and 8-isoprostane by 50 mu g/mL PM2.5 extracts was determined in A549 cells in vitro. Moderate heterogeneities were shown in PM2.5 exposures and the corresponding PM2.5 bioreactivity across different sample types. Associations between the analyzed components and PM2.5 bioreactivity were assessed using the multiple regression models. Toxicological results revealed that indoor and personal exposure to OC as well as PAH compounds and their derivatives (e.g., Alkyl-PAHs, Oxy-PAHs) induced cell viability reduction and increase in levels of LDH, IL-6, and 8-isoprostane. Overall, OC in personal exposure played a dominant role in PM2.5-induced bioreactivity. Subsequently, we examined the associations of FeNO with IL-6 and 8-isoprostane levels using mixed-effects models. The results showed that per interquartile change in IL-6 and 8-isoprostane were associated with a 6.4% (p < 0.01) and 11.1% (p < 0.01) increase in FeNO levels, respectively. Our study explored the toxicological properties of chemical components in PM2.5 exposure, which suggested that residential indoors and personal OC and PAHs should be of great concern for human health. These findings indicated that further studies in inflammation and oxidative stress-related illnesses due to particle exposure would benefit from the assessment of in vitro PM2.5 bioreactivity. |
| WOS关键词 | FINE PARTICULATE MATTER ; POLYCYCLIC-AROMATIC-HYDROCARBONS ; OXIDATIVE STRESS ; AIR-POLLUTION ; PARTICLES PM2.5 ; INDOOR/OUTDOOR RELATIONSHIPS ; CIRCULATING BIOMARKERS ; CHINESE MEGACITY ; RISK-ASSESSMENT ; AMBIENT |
| 资助项目 | Research Grants Council of the Hong Kong Special Administrative Region of China[412413] |
| WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health |
| 语种 | 英语 |
| WOS记录号 | WOS:000564651700015 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 资助机构 | Research Grants Council of the Hong Kong Special Administrative Region of China |
| 源URL | [http://ir.ieecas.cn/handle/361006/15255]  |
| 专题 | 地球环境研究所_粉尘与环境研究室 |
| 通讯作者 | Ho, Kin-Fai |
| 作者单位 | 1.Chinese Univ Hong Kong, Inst Environm Energy & Sustainabil, Hong Kong, Peoples R China 2.Taipei Med Univ, Coll Med, Sch Resp Therapy, Taipei, Taiwan 3.Univ Montana, Sch Publ & Community Hlth Sci, Missoula, MT 59812 USA 4.Univ Hong Kong, Sch Publ Hlth, Hong Kong, Peoples R China 5.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol, SKLLQG, Xian, Peoples R China 6.Xi An Jiao Tong Univ, Inst Global Environm Change, Xian, Peoples R China 7.Chinese Univ Hong Kong, Dept Geog & Resource Management, Hong Kong, Peoples R China 8.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China 9.Natl Taiwan Univ, Grad Inst Environm Engn, Taipei, Taiwan 10.Chinese Univ Hong Kong, Shenzhen Res Inst, Shenzhen, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Xiao-Cui,Chuang, Hsiao-Chi,Ward, Tony J.,et al. Indoor, outdoor, and personal exposure to PM2.5 and their bioreactivity among healthy residents of Hong Kong[J]. ENVIRONMENTAL RESEARCH,2020,188:13. |
| APA | Chen, Xiao-Cui.,Chuang, Hsiao-Chi.,Ward, Tony J..,Tian, Linwei.,Cao, Jun-Ji.,...&Ho, Kin-Fai.(2020).Indoor, outdoor, and personal exposure to PM2.5 and their bioreactivity among healthy residents of Hong Kong.ENVIRONMENTAL RESEARCH,188,13. |
| MLA | Chen, Xiao-Cui,et al."Indoor, outdoor, and personal exposure to PM2.5 and their bioreactivity among healthy residents of Hong Kong".ENVIRONMENTAL RESEARCH 188(2020):13. |
入库方式： OAI收割
来源：地球环境研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。