Biotoxic effects and gene expression regulation of urban PM2.5 in southwestern China
文献类型：期刊论文
| 作者 | Zhang, Shumin1,2; Zhang, Jingping1; Guo, Dongmei1; Peng, Chao2; Tian, Mi3; Pei, Desheng2; Wang, Qiyuan4,5; Yang, Fumo6; Cao, Junji4,5; Chen, Yang2 |
| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
 |
| 出版日期 | 2021-01-20 |
| 卷号 | 753页码:11 |
| ISSN号 | 0048-9697 |
| 关键词 | PM2.5 Biotoxic Transcriptome Chengdu Chongqing Southwestern China |
| DOI | 10.1016/j.scitotenv.2020.141774 |
| 通讯作者 | Pei, Desheng(peids@cigit.ac.cn) ; Chen, Yang(chenyang@cigit.ac.cn) |
| 英文摘要 | Atmospheric fine particulate matter (PM2.5) causes severe haze in China and is regarded as a threat to human health. The health effects of PM2.5 vary location by location due to the variation in size distribution, chemical composition, and sources. In this study, the cytotoxicity effect, oxidative stress, and gene expression regulation of PM2.5 in Chengdu and Chongqing, two typical urban areas in southern China, were evaluated. Urban PM2.5 in summer and winter significantly inhibited cell viability and increased reactive oxygen species (ROS) levels in A549 cells. Notably, PM2.5 in winter exhibited higher cytotoxicity and ROS level than summer. Moreover, in this study, PM2.5 commonly induced cancer-related gene expression such as cell adhesion molecule 1 (PECAM1), interleukin 24 (IL24), and cytochrome P450 (CYP1A1); meanwhile, PM2.5 commonly acted on cancer-related biological functions such as cell-substrate junction, cell-cell junction, and focal adhesion. In particular, PM2.5 in Chengdu in summer had the highest carcinogenic potential among PM2.5 at the two sites in summer and winter. Importantly, cancer-related genes were uniquely targeted by PM2.5, such as epithelial splicing regulatory protein 1 (ESRP1) and membrane-associated ring-CH-type finger 1 (1-Mar) by Chengdu summer PM2.5; collagen type IX alpha 3 chain (COL9A3) by Chengdu winter PM2.5; SH2 domain-containing 1B (SH2D1B) by Chongqing summer PM2.5; and interleukin 1 receptor-like 1 (IL1RL1) and zinc finger protein 42 (ZNF423) by Chongqing winter PM2.5. Meanwhile, important cancer-related biological functions were specially induced byPM(2.5), such as cell cycle checkpoint by Chengdu summer PM2.5; macromolecule methylation by Chengdu winter PM2.5; endoplasmic reticulum-Golgi intermediate compartment membrane by Chongqing summer PM2.5; and cellular lipid catabolic process by Chongqing winter PM2.5. Conclusively, in the typical urban areas of southern China, both summer andwinter PM2.5 illustrated significant gene regulation effects. This study contributes to evaluating the adverse health effects of PM2.5 in southern China and providing public health suggestions for policymakers. (C) 2020 Published by Elsevier B.V. |
| WOS关键词 | LONG-TERM EXPOSURE ; PARTICULATE MATTER ; AIR-POLLUTION ; CANCER ; PARTICLES ; MECHANISMS ; RECEPTORS ; MORTALITY ; TOXICITY ; CLIMATE |
| 资助项目 | Nanchong Science and Technology Project[18SXHZ0573] ; PhD Research Fund of North Sichuan Medical College[CBY19-QD04] |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000588616700019 |
| 资助机构 | Nanchong Science and Technology Project ; PhD Research Fund of North Sichuan Medical College |
| 源URL | [http://ir.ieecas.cn/handle/361006/15528]  |
| 专题 | 地球环境研究所_粉尘与环境研究室 |
| 通讯作者 | Pei, Desheng; Chen, Yang |
| 作者单位 | 1.North Sichuan Med Coll, Sch Basic Med Sci, Nanchong 637000, Sichuan, Peoples R China 2.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China 3.Chongqing Univ, Sch Urban Construct & Environm Engn, Chongqing 400044, Peoples R China 4.Chinese Acad Sci, Inst Earth Environm, State Key Lab Loess & Quaternary Geol SKLLQG, Xian 710075, Peoples R China 5.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol Chem & Phys KLACP, Xian 710075, Peoples R China 6.Sichuan Univ, Coll Architecture & Environm, Chengdu 610065, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Shumin,Zhang, Jingping,Guo, Dongmei,et al. Biotoxic effects and gene expression regulation of urban PM2.5 in southwestern China[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2021,753:11. |
| APA | Zhang, Shumin.,Zhang, Jingping.,Guo, Dongmei.,Peng, Chao.,Tian, Mi.,...&Chen, Yang.(2021).Biotoxic effects and gene expression regulation of urban PM2.5 in southwestern China.SCIENCE OF THE TOTAL ENVIRONMENT,753,11. |
| MLA | Zhang, Shumin,et al."Biotoxic effects and gene expression regulation of urban PM2.5 in southwestern China".SCIENCE OF THE TOTAL ENVIRONMENT 753(2021):11. |
入库方式： OAI收割
来源：地球环境研究所
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