Diterpenoids from the Root Bark of Pinus massoniana and Evaluation of Their Phosphodiesterase Type 4D Inhibitory Activity
文献类型：期刊论文
| 作者 | Fu, Yifan2,3; Ding, Xiaoyu1,2; Zhang, Xianglei1,2; Shao, Xingcheng2,3; Zhao, Jihui1,2; Xu, Yechun1,2 ; Luo, Xiaomin1,2; Zhao, Weimin2,3
|
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2020-04-24 |
| 卷号 | 83期号:4页码:1229-1237 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.9b01269 |
| 通讯作者 | Xu, Yechun(ycxu@simm.ac.cn) ; Luo, Xiaomin(xmluo@simm.ac.cn) ; Zhao, Weimin(wmzhao@simm.ac.cn) |
| 英文摘要 | Thirty-two diterpenoids were obtained from the root bark of Pinus massoniana, and, among them, five compounds (pinmassins A-E) were identified as undescribed analogues. Spectroscopic methods, X-ray single-crystal diffraction analysis, and ECD calculations were applied to establish the structure of the new isolates. Pinmassin D (4) and abieta-8,11,13,15-tetraen-18-oic acid (23) showed moderate phosphodiesterase type 4D (PDE4D) inhibitory effects with IC50 values of 2.8 +/- 0.18 and 3.3 +/- 0.50 mu M, respectively, and their binding modes were investigated by a molecular docking study. |
| WOS关键词 | ABIETANE DITERPENOIDS ; ACID ; CYTOTOXICITY ; CONSTITUENTS ; DOCKING ; LIGNAN ; LEAVES ; GLIDE ; RESIN ; MODEL |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000529168400044 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/291704]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xu, Yechun; Luo, Xiaomin; Zhao, Weimin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Prod Chem, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Yifan,Ding, Xiaoyu,Zhang, Xianglei,et al. Diterpenoids from the Root Bark of Pinus massoniana and Evaluation of Their Phosphodiesterase Type 4D Inhibitory Activity[J]. JOURNAL OF NATURAL PRODUCTS,2020,83(4):1229-1237. |
| APA | Fu, Yifan.,Ding, Xiaoyu.,Zhang, Xianglei.,Shao, Xingcheng.,Zhao, Jihui.,...&Zhao, Weimin.(2020).Diterpenoids from the Root Bark of Pinus massoniana and Evaluation of Their Phosphodiesterase Type 4D Inhibitory Activity.JOURNAL OF NATURAL PRODUCTS,83(4),1229-1237. |
| MLA | Fu, Yifan,et al."Diterpenoids from the Root Bark of Pinus massoniana and Evaluation of Their Phosphodiesterase Type 4D Inhibitory Activity".JOURNAL OF NATURAL PRODUCTS 83.4(2020):1229-1237. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。