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Four new indole alkaloids from the roots ofIsatis tinctoria

文献类型：期刊论文

作者Zhang, Dongdong1,2; Sun, Yu2; Shi, Yanhong3; Wu, Ximin1; Jia, Qi1; Chen, Kaixian1,4; Li, Yiming1; Wang, Rui1
刊名NATURAL PRODUCT RESEARCH
出版日期2020-06-18
页码7
关键词Isatis tinctoriaL indole alkaloids isatisindigoticanine L - N isatindigoside M inhibitory of NO production
ISSN号1478-6419
DOI10.1080/14786419.2020.1779716
通讯作者Li, Yiming(ymlius@163.com) ; Wang, Rui(wr@shutcm.edu.cn)
英文摘要Chemical fractionation of the ethanolic extract of the roots ofIsatis tinctoriaL. (I. tinctoria) yielded fourteen indole alkaloids including four new ones, isatisindigoticanine L-N and isatindigoside M. Their structures were established on the basis of extensive spectroscopic techniques including NMR, HRESIMS and IR as well as chemical methods. The absolute configuration of1was confirmed by ECD experiments. All the compounds were tested for their inhibitory effects on NO production in mouse mononuclear macrophages (RAW264.7) induced by lipopolysaccharide (LPS). The results showed that only compound5exhibited inhibitory effects with IC(50)value of 18.5 mu M.
WOS关键词CHEMICAL-CONSTITUENTS ; ISATIS-INDIGOTICA ; DERIVATIVES ; ACID ; GLYCOSIDES
资助项目National Natural Science Foundation of China[81573571] ; National Natural Science Foundation of China[81673570] ; Excellent Academic Leaders Program of Shanghai[16XD1403500] ; Shanghai Scientific and Technological Innovation Program[18401931100]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000547754300001
出版者TAYLOR & FRANCIS LTD
源URL[http://119.78.100.183/handle/2S10ELR8/291811]  
专题中国科学院上海药物研究所
通讯作者Li, Yiming; Wang, Rui
作者单位1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R China
2.Shaanxi Univ Chinese Med, Sch Pharm, Xianyang, Peoples R China
3.Shanghai Univ Tradit Chinese Med, Inst TCM Int Standardizat, Shanghai, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Dongdong,Sun, Yu,Shi, Yanhong,et al. Four new indole alkaloids from the roots ofIsatis tinctoria[J]. NATURAL PRODUCT RESEARCH,2020:7.
APA Zhang, Dongdong.,Sun, Yu.,Shi, Yanhong.,Wu, Ximin.,Jia, Qi.,...&Wang, Rui.(2020).Four new indole alkaloids from the roots ofIsatis tinctoria.NATURAL PRODUCT RESEARCH,7.
MLA Zhang, Dongdong,et al."Four new indole alkaloids from the roots ofIsatis tinctoria".NATURAL PRODUCT RESEARCH (2020):7.

入库方式： OAI收割

来源：上海药物研究所

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