Supramolecular Drug-Drug Complex Vesicles Enable Sequential Drug Release for Enhanced Combination Therapy
文献类型：期刊论文
| 作者 | Liu, Chengfei3; Li, Chunpu1; Pang, Cui2; Li, Muqiong2; Li, Huixin3; Li, Pengxiang3; Fan, Li2; Liu, Hong1 ; Tian, Wei3
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| 刊名 | ACS APPLIED MATERIALS & INTERFACES
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| 出版日期 | 2020-06-24 |
| 卷号 | 12期号:25页码:27940-27950 |
| 关键词 | drug-drug self-delivery system supramolecular vesicles host-guest interaction self-assembly pillar[5]arene combination therapy |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.0c04565 |
| 通讯作者 | Fan, Li(xxfanny@fmmu.edu.cn) ; Liu, Hong(hliu@simm.ac.cn) ; Tian, Wei(happytw_3000@nwpu.edu.cn) |
| 英文摘要 | Drug-drug self-delivery systems serving as both carriers and cargos have been explored as advanced combination chemotherapy strategies to overcome the limitations of the traditional single-drug chemotherapy. However, most known drug-drug self-delivery systems may cause a rapid increase in drug concentration when the single covalent bond is broken, thus leading to high toxicity to organs and low therapeutic efficiency against tumors. To address the above problem, in this study, a novel supramolecular drug-drug complex (SDDC) simultaneously containing both covalent and noncovalent bonds was proposed to realize the sequential release of two drugs in tumor cells for enhanced combination therapy. The SDDC could self-assemble into uniform bilayer supramolecular vesicles (SVs) with a remarkable drug loading capacity and stable drug transport. Notably, the SVs with controlled sequential release ability in tumor cells exhibited a superior synergistic effect and significantly improved therapeutic efficiency with reduced toxicity in in vivo antitumor activity and histological analyses in comparison to either individual free drugs or a mixture of two free drugs. Therefore, by combining the advantages of noncovalent interactions with the dynamic nature and stable covalent bonds, this study opens a new way for cancer therapy. |
| WOS关键词 | DELIVERY SYSTEMS ; CO-DELIVERY ; CANCER ; CHEMOTHERAPY ; GEMCITABINE ; PRODRUG ; PACLITAXEL ; HOST |
| 资助项目 | National Science Foundation of China[21674086] ; National Science Foundation of China[21632008] ; National Science Foundation of China[81771972] ; National Science Foundation of China[81620108027] ; National Key Research and Development Program of China[2017YFC0107405] ; Natural Science Basic Research Plan in Shaanxi Province of China[2020JC-20] ; Natural Science Basic Research Plan in Shaanxi Province of China[2018JZ2003] ; Innovation talents promotion plan of Shaanxi province[2019KJXX-083] ; Fundamental Research Funds for the Central Universities[3102019PY003] |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000543780900009 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/291922]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Fan, Li; Liu, Hong; Tian, Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Air Force Med Univ, Dept Pharmaceut Chem & Anal, Sch Pharm, Xian 710032, Shaanxi, Peoples R China 3.Northwestern Polytech Univ, Shaanxi Key Lab Macromol Sci & Technol, MOE Key Lab Mat Phys & Chem Extraordinary Condit, Sch Chem & Chem Engn, Xian 710072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Chengfei,Li, Chunpu,Pang, Cui,et al. Supramolecular Drug-Drug Complex Vesicles Enable Sequential Drug Release for Enhanced Combination Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2020,12(25):27940-27950. |
| APA | Liu, Chengfei.,Li, Chunpu.,Pang, Cui.,Li, Muqiong.,Li, Huixin.,...&Tian, Wei.(2020).Supramolecular Drug-Drug Complex Vesicles Enable Sequential Drug Release for Enhanced Combination Therapy.ACS APPLIED MATERIALS & INTERFACES,12(25),27940-27950. |
| MLA | Liu, Chengfei,et al."Supramolecular Drug-Drug Complex Vesicles Enable Sequential Drug Release for Enhanced Combination Therapy".ACS APPLIED MATERIALS & INTERFACES 12.25(2020):27940-27950. |
入库方式： OAI收割
来源：上海药物研究所
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