Bisindole alkaloids with nitric oxide inhibitory activities from an alcohol extract of the Isatis indigotica roots
文献类型：期刊论文
| 作者 | Zhang, Dongdong1,2; Sun, Yu1; Chen, Zhaoqiang3; Jia, Qi2; Zhu, Weiliang3 ; Chen, Kaixian2,3; Li, Yiming2; Wang, Rui2
|
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2020-10-01 |
| 卷号 | 146页码:5 |
| 关键词 | Isatis indigotica Bisindole alkaloids Nitric oxide production Isatisindigoticanines J and K Isatindigosides H-J |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2020.104654 |
| 通讯作者 | Li, Yiming(ymlius@163.com) ; Wang, Rui(wr@shutcm.edu.cn) |
| 英文摘要 | Eight bisindole alkaloids including six undescribed ones (1a/1b-5) were isolated from an alcohol extract of the Isatis indigotica roots. Their structures and absolute configurations were supported by extensive spectroscopic data analysis, including 1D, 2D NMR, HRESIMS data, specific rotation data, and comparison of the experimental and calculated ECD data. Compounds 1a and 1b were determined to be a pair of enantiomers with a ratio of approximately 1:1 by chiral-phase chromatography analysis while compound 4 was elucidated as a new type of bisindole alkaloid with the aglycone categorized as bis(indole-1'/3 ''-yl)methane. All the isolated compounds were tested for their nitric oxide (NO) inhibitory effects and 1-4 and 6 exhibited inhibitory effects with IC50 values ranging from 11.0 to 37.6 mu M. |
| WOS关键词 | GLYCOSIDES ; GLUCOSIDES |
| 资助项目 | National Natural Science Foundation of China[81573571] ; National Natural Science Foundation of China[81673570] ; Excellent Academic Leaders Program of Shanghai[16XD1403500] ; programs of High level University Innovation Team, Shanghai E-Research Institute of Bioactive Constituents in Traditional Chinese Medicine ; Shanghai Scientific and Technological Innovation Program[18401931100] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000580427700008 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/292507]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Yiming; Wang, Rui |
| 作者单位 | 1.Shaanxi Univ Chinese Med, Sch Pharm, Xianyang 712046, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Dongdong,Sun, Yu,Chen, Zhaoqiang,et al. Bisindole alkaloids with nitric oxide inhibitory activities from an alcohol extract of the Isatis indigotica roots[J]. FITOTERAPIA,2020,146:5. |
| APA | Zhang, Dongdong.,Sun, Yu.,Chen, Zhaoqiang.,Jia, Qi.,Zhu, Weiliang.,...&Wang, Rui.(2020).Bisindole alkaloids with nitric oxide inhibitory activities from an alcohol extract of the Isatis indigotica roots.FITOTERAPIA,146,5. |
| MLA | Zhang, Dongdong,et al."Bisindole alkaloids with nitric oxide inhibitory activities from an alcohol extract of the Isatis indigotica roots".FITOTERAPIA 146(2020):5. |
入库方式： OAI收割
来源：上海药物研究所
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