Synthesis of CBD and Its Derivatives Bearing Various C4 '-Side Chains with a Late-Stage Diversification Method
文献类型：期刊论文
| 作者 | Gong, XD (Gong, Xudong)[ 2,3 ]; Sun, CL (Sun, Changliang)[ 4 ]; Abame, MA (Abame, Melkamu Alemu)[ 1 ]; Shi, WQ (Shi, Wenqiang)[ 1 ]; Xie, YC (Xie, Yuanchao)[ 1 ]; Xu, WB (Xu, Wanbin)[ 1 ]; Zhu, FQ (Zhu, Fuqiang)[ 4 ]; Zhang, Y (Zhang, Yan)[ 1 ]; Shen, JS (Shen, Jingshan)[ 1 ]; Aisa, HA (Aisa, Haji A.)[ 2 ]
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
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| 出版日期 | 2020 |
| 卷号 | 85期号:4页码:2704-2715 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.9b02880 |
| 英文摘要 | A novel synthetic route for making (-)-CBD and its derivatives bearing various C4'-side chains is developed by a late-stage diversification method. Starting from commercially available phloroglucinol, the key intermediate (-)-CBD-2OPiv-OTf is efficiently and regioselectively prepared and further undergoes Negishi cross-coupling to furnish (-)-CBD. This approach allowed an efficient synthesis of (-)-CBD in a five-step total 52% yield on a 10 g scale. Furthermore, diversification on the C4'-side chain with this method can be realized in a wide range. |
| WOS记录号 | WOS:000516665800084 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/7281]  |
| 专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 新疆理化技术研究所_资源化学研究室 |
| 通讯作者 | Aisa, HA (Aisa, Haji A.)[ 2 ] |
| 作者单位 | 1.Topharman Shanghai Co Ltd, Shanghai, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gong, XD ,Sun, CL ,Abame, MA ,et al. Synthesis of CBD and Its Derivatives Bearing Various C4 '-Side Chains with a Late-Stage Diversification Method[J]. JOURNAL OF ORGANIC CHEMISTRY,2020,85(4):2704-2715. |
| APA | Gong, XD .,Sun, CL .,Abame, MA .,Shi, WQ .,Xie, YC .,...&Aisa, HA .(2020).Synthesis of CBD and Its Derivatives Bearing Various C4 '-Side Chains with a Late-Stage Diversification Method.JOURNAL OF ORGANIC CHEMISTRY,85(4),2704-2715. |
| MLA | Gong, XD ,et al."Synthesis of CBD and Its Derivatives Bearing Various C4 '-Side Chains with a Late-Stage Diversification Method".JOURNAL OF ORGANIC CHEMISTRY 85.4(2020):2704-2715. |
入库方式： OAI收割
来源：新疆理化技术研究所
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