Spirodesertols A and B, two highly modified spirocyclic diterpenoids with an unprecedented 6-isopropyl-3H-spiro[benzofuran-2,1 ' cyclohexane] motif from Salvia deserta
文献类型:期刊论文
作者 | Zheng, GJ (Zheng, Guijuan)[ 1,2 ]; Kadir, A (Kadir, Abdukriem)[ 1 ]; Zheng, XF (Zheng, Xiaofeng)[ 2 ]; Jin, PF (Jin, Pengfei)[ 2 ]; Liu, JJ (Liu, Junjun)[ 2 ]; Maiwulanjiang, M (Maiwulanjiang, Maitinuer)[ 1 ]; Yao, GM (Yao, Guangmin)[ 1,2 ]; Aisa, HA (Aisa, Haji Akber)[ 1 ] |
刊名 | ORGANIC CHEMISTRY FRONTIERS |
出版日期 | 2020 |
卷号 | 7期号:20页码:3137-3145 |
ISSN号 | 2052-4129 |
DOI | 10.1039/d0qo00735h |
英文摘要 | Two highly modified spirocyclic diterpenoids with an unprecedented 6-isopropyl-3H-spiro[benzofuran2,1'-cyclohexane] motif, spirodesertols A (1) and B (2), four new icetexane diterpenoids, salviadenones A-D (3-6), together with their biogenetic precursor, 20-deoxocarnosol (7), were isolated from the root extract of Salvia deserta. Their structures were elucidated by spectroscopic analysis, quantum chemical calculations including the 13C chemical shift calculations with DP4+ probability analysis and electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction analysis. The plausible biogenetic pathways for 1-6 were proposed. Compounds 1-7 were evaluated for their cytotoxicity against five cancer cell lines. Spirodesertol A (1) showed more potent cytotoxicity against the A-549, SMMC-7721, and MCF-7 cancer cell lines than the positive control, cisplatin. |
WOS记录号 | WOS:000579143200022 |
源URL | [http://ir.xjipc.cas.cn/handle/365002/7433] |
专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 新疆理化技术研究所_资源化学研究室 |
通讯作者 | Aisa, HA (Aisa, Haji Akber)[ 1 ] |
作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China 2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Xinjiang, Peoples R China |
推荐引用方式 GB/T 7714 | Zheng, GJ ,Kadir, A ,Zheng, XF ,et al. Spirodesertols A and B, two highly modified spirocyclic diterpenoids with an unprecedented 6-isopropyl-3H-spiro[benzofuran-2,1 ' cyclohexane] motif from Salvia deserta[J]. ORGANIC CHEMISTRY FRONTIERS,2020,7(20):3137-3145. |
APA | Zheng, GJ .,Kadir, A .,Zheng, XF .,Jin, PF .,Liu, JJ .,...&Aisa, HA .(2020).Spirodesertols A and B, two highly modified spirocyclic diterpenoids with an unprecedented 6-isopropyl-3H-spiro[benzofuran-2,1 ' cyclohexane] motif from Salvia deserta.ORGANIC CHEMISTRY FRONTIERS,7(20),3137-3145. |
MLA | Zheng, GJ ,et al."Spirodesertols A and B, two highly modified spirocyclic diterpenoids with an unprecedented 6-isopropyl-3H-spiro[benzofuran-2,1 ' cyclohexane] motif from Salvia deserta".ORGANIC CHEMISTRY FRONTIERS 7.20(2020):3137-3145. |
入库方式: OAI收割
来源:新疆理化技术研究所
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