中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Hypoglycemic and hypolipidemic effects of Moringa oleifera leaves and their functional chemical constituents

文献类型:期刊论文

作者Chen, Gui-Lin2,3,4; Xu, Yong-Bing2,3,4,5; Wu, Jian-Lin1; Li, Na1; Guo, Ming-Quan2,3,4
刊名FOOD CHEMISTRY
出版日期2020-12-15
卷号333页码:9
ISSN号0308-8146
关键词Moringa oleifera Hyperglycemia Hyperlipidemia alpha-glucosidase Pancreatic lipase UF-LC/MS
DOI10.1016/j.foodchem.2020.127478
英文摘要Moringa oleifera Lam. (M. oleifera) leaves have long been consumed as both nutritive vegetable and popular folk medicine for hyperglycemia and hyperlipidemia in Kenya communities. In the current study, in vitro inhibition by M. oleifera leaf extract (MOLE, 90% (v/v) ethanol) of alpha-glucosidase and pancreatic lipase was demonstrated, followed by determination of the effects of MOLE on both glucose consumption and lipid levels (TC, TG, HDL-C and LDL-C) in 3T3-L1 cells. Potential ligands in MOLE were fast screened using affinity ultrafiltration LC-MS, and 14 and 10 components displayed certain binding affinity to alpha-glucosidase and pancreatic lipase, respectively. Docking studies revealed the binding energies and hydrogen bonds between potential ligands and enzymes. This study suggests that M. oleifera leaves may be a promising natural source for the prevention and treatment of hyperglycemia and hyperlipidemia as well as a functional food or other product for health care in the near future.
资助项目Natural Science Foundation of China[81673580] ; Natural Science Foundation of China[81903791] ; Natural Science Foundation of Hubei Province[2019CFB254] ; Macao Science and Technology Development Fund[0090/2018/A3]
WOS研究方向Chemistry ; Food Science & Technology ; Nutrition & Dietetics
语种英语
出版者ELSEVIER SCI LTD
WOS记录号WOS:000567774300021
源URL[http://202.127.146.157/handle/2RYDP1HH/15672]  
专题中国科学院武汉植物园
通讯作者Guo, Ming-Quan
作者单位1.Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Taipa, Macao, Peoples R China
2.Chinese Acad Sci, Wuhan Bot Garden, Key Lab Plant Germplasm Enhancement & Specialty A, Wuhan, Peoples R China
3.Chinese Acad Sci, Sino Africa Joint Res Ctr, Wuhan, Peoples R China
4.Chinese Acad Sci, Innovat Acad Drug Discovery & Dev, Shanghai, Peoples R China
5.Grad Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Chen, Gui-Lin,Xu, Yong-Bing,Wu, Jian-Lin,et al. Hypoglycemic and hypolipidemic effects of Moringa oleifera leaves and their functional chemical constituents[J]. FOOD CHEMISTRY,2020,333:9.
APA Chen, Gui-Lin,Xu, Yong-Bing,Wu, Jian-Lin,Li, Na,&Guo, Ming-Quan.(2020).Hypoglycemic and hypolipidemic effects of Moringa oleifera leaves and their functional chemical constituents.FOOD CHEMISTRY,333,9.
MLA Chen, Gui-Lin,et al."Hypoglycemic and hypolipidemic effects of Moringa oleifera leaves and their functional chemical constituents".FOOD CHEMISTRY 333(2020):9.

入库方式: OAI收割

来源:武汉植物园

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