Hypoglycemic and hypolipidemic effects of Moringa oleifera leaves and their functional chemical constituents
文献类型:期刊论文
作者 | Chen, Gui-Lin2,3,4; Xu, Yong-Bing2,3,4,5; Wu, Jian-Lin1; Li, Na1; Guo, Ming-Quan2,3,4 |
刊名 | FOOD CHEMISTRY |
出版日期 | 2020-12-15 |
卷号 | 333页码:9 |
ISSN号 | 0308-8146 |
关键词 | Moringa oleifera Hyperglycemia Hyperlipidemia alpha-glucosidase Pancreatic lipase UF-LC/MS |
DOI | 10.1016/j.foodchem.2020.127478 |
英文摘要 | Moringa oleifera Lam. (M. oleifera) leaves have long been consumed as both nutritive vegetable and popular folk medicine for hyperglycemia and hyperlipidemia in Kenya communities. In the current study, in vitro inhibition by M. oleifera leaf extract (MOLE, 90% (v/v) ethanol) of alpha-glucosidase and pancreatic lipase was demonstrated, followed by determination of the effects of MOLE on both glucose consumption and lipid levels (TC, TG, HDL-C and LDL-C) in 3T3-L1 cells. Potential ligands in MOLE were fast screened using affinity ultrafiltration LC-MS, and 14 and 10 components displayed certain binding affinity to alpha-glucosidase and pancreatic lipase, respectively. Docking studies revealed the binding energies and hydrogen bonds between potential ligands and enzymes. This study suggests that M. oleifera leaves may be a promising natural source for the prevention and treatment of hyperglycemia and hyperlipidemia as well as a functional food or other product for health care in the near future. |
资助项目 | Natural Science Foundation of China[81673580] ; Natural Science Foundation of China[81903791] ; Natural Science Foundation of Hubei Province[2019CFB254] ; Macao Science and Technology Development Fund[0090/2018/A3] |
WOS研究方向 | Chemistry ; Food Science & Technology ; Nutrition & Dietetics |
语种 | 英语 |
出版者 | ELSEVIER SCI LTD |
WOS记录号 | WOS:000567774300021 |
源URL | [http://202.127.146.157/handle/2RYDP1HH/15672] |
专题 | 中国科学院武汉植物园 |
通讯作者 | Guo, Ming-Quan |
作者单位 | 1.Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Taipa, Macao, Peoples R China 2.Chinese Acad Sci, Wuhan Bot Garden, Key Lab Plant Germplasm Enhancement & Specialty A, Wuhan, Peoples R China 3.Chinese Acad Sci, Sino Africa Joint Res Ctr, Wuhan, Peoples R China 4.Chinese Acad Sci, Innovat Acad Drug Discovery & Dev, Shanghai, Peoples R China 5.Grad Univ Chinese Acad Sci, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Chen, Gui-Lin,Xu, Yong-Bing,Wu, Jian-Lin,et al. Hypoglycemic and hypolipidemic effects of Moringa oleifera leaves and their functional chemical constituents[J]. FOOD CHEMISTRY,2020,333:9. |
APA | Chen, Gui-Lin,Xu, Yong-Bing,Wu, Jian-Lin,Li, Na,&Guo, Ming-Quan.(2020).Hypoglycemic and hypolipidemic effects of Moringa oleifera leaves and their functional chemical constituents.FOOD CHEMISTRY,333,9. |
MLA | Chen, Gui-Lin,et al."Hypoglycemic and hypolipidemic effects of Moringa oleifera leaves and their functional chemical constituents".FOOD CHEMISTRY 333(2020):9. |
入库方式: OAI收割
来源:武汉植物园
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