One-Pot Synthesis of Epirubicin-Capped Silver Nanoparticles and Their Anticancer Activity against Hep G2 Cells
文献类型：期刊论文
| 作者 | Ding, Jun1,2; Chen, Guilin1,3; Chen, Guofang4; Guo, Mingquan1,3 |
| 刊名 | PHARMACEUTICS
 |
| 出版日期 | 2019-03-01 |
| 卷号 | 11期号:3页码:7 |
| 关键词 | epirubicin one-pot synthesis silver nanoparticle antitumor |
| ISSN号 | 1999-4923 |
| DOI | 10.3390/pharmaceutics11030123 |
| 英文摘要 | Epirubicin-capped silver nanoparticles (NPs) were synthesized through a one-pot method by using epirubicin as both the functional drug and the reducing agent of Ag+ to Ag-0. The preparation process was accomplished in 1 h. In addition, the obtained epirubicin-capped silver nanoparticle was characterized by transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), and infrared spectroscopy. The results showed that a layer of polymer epirubicin had formed around the silver nanoparticle, which was 30-40 nm in diameter. We further investigated the antitumor activity of the prepared epirubicin-capped silver nanoparticle, and the half maximal inhibitory concentration (IC50) against Hep G2 cells was 1.92 g/mL, indicating a good antitumor property of the nanoparticle at low dosage. |
| 资助项目 | Natural Science Foundation of China[51428303] ; Natural Science Foundation of China[81673580] ; Major Project of Hubei Province for Special Technology Innovation[2017AHB054] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000466897800025 |
| 出版者 | MDPI |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/7272]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Chen, Guofang; Guo, Mingquan |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Plant Germplasm Enhancement & Specialty A, Wuhan Bot Garden, Wuhan 430074, Hubei, Peoples R China 2.Wuhan Univ, Dept Chem, Key Lab Analyt Chem Biol & Med, Minist Educ, Wuhan 430072, Hubei, Peoples R China 3.Chinese Acad Sci, Sino Africa Joint Res Ctr, Wuhan 430074, Hubei, Peoples R China 4.St Johns Univ, Chem Dept, New York, NY 11439 USA |
| 推荐引用方式 GB/T 7714 | Ding, Jun,Chen, Guilin,Chen, Guofang,et al. One-Pot Synthesis of Epirubicin-Capped Silver Nanoparticles and Their Anticancer Activity against Hep G2 Cells[J]. PHARMACEUTICS,2019,11(3):7. |
| APA | Ding, Jun,Chen, Guilin,Chen, Guofang,&Guo, Mingquan.(2019).One-Pot Synthesis of Epirubicin-Capped Silver Nanoparticles and Their Anticancer Activity against Hep G2 Cells.PHARMACEUTICS,11(3),7. |
| MLA | Ding, Jun,et al."One-Pot Synthesis of Epirubicin-Capped Silver Nanoparticles and Their Anticancer Activity against Hep G2 Cells".PHARMACEUTICS 11.3(2019):7. |
入库方式： OAI收割
来源：武汉植物园
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