Cardiolipin-Dependent Mitophagy Guides Outcome after Traumatic Brain Injury
文献类型：期刊论文
| 作者 | Chao, Honglu1,2,4; Lin, Chao2; Liu, Yinlong2; Xu, Xiupeng2; Li, Zheng2; Bao, Zhongyuan2; You, Yongping2; Liu, Ning2; Ji, Jing1,2,4; Zuo, Qiang3 |
| 刊名 | JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2019 |
| 卷号 | 39期号:10页码:1930-1943 |
| 关键词 | apoptosis autophagy cardiolipin mitophagy neuroprotection phospholipid |
| ISSN号 | 0270-6474 |
| DOI | 10.1523/JNEUROSCI.3415-17.2018 |
| 文献子类 | Article |
| 英文摘要 | Mitochondrial energy production is essential for normal brain function. Traumatic brain injury (TBI) increases brain energy demands, results in the activation of mitochondrial respiration, associated with enhanced generation of reactive oxygen species. This chain of events triggers neuronal apoptosis via oxidation of a mitochondria-specific phospholipid, cardiolipin (CL). One pathway through which cells can avoid apoptosis is via elimination of damaged mitochondria by mitophagy. Previously, we showed that externalization of CL to the mitochondrial surface acts as an elimination signal in cells. Whether CL-mediated mitophagy occurs in vivo or its significance in the disease processes are not known. In this study, we showed that TBI leads to increased mitophagy in the human brain, which was also detected using TBI models in male rats. Knockdown of CL synthase, responsible for de novo synthesis of CL, or phospholipid scramblase-3, responsible for CL translocat ion to the outer mitochondrial membrane, significantly decreased TBI-induced mitophagy. Inhibition of mitochondrial clearance by 3-methyladenine, mdivi-1, or phospholipid scramblase-3 knockdown after TBI led to a worse outcome, suggesting that mitophagy is beneficial. Together, our findings indicate that TBI-induced mitophagy is an endogenous neuroprotective process that is directed by CL, which marks damaged mitochondria for elimination, thereby limiting neuronal death and behavioral deficits. |
| 学科主题 | Neurosciences & Neurology |
| WOS关键词 | DYNAMIN-RELATED PROTEIN-1 ; AUTOPHAGIC CELL-DEATH ; PHOSPHOLIPID SCRAMBLASE-3 ; MITOCHONDRIAL FISSION ; PATHWAY ; ELIMINATION ; PARKIN ; SIGNAL ; MICE ; DRP1 |
| 语种 | 英语 |
| WOS记录号 | WOS:000460403400014 |
| 出版者 | SOC NEUROSCIENCE |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/489]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Pittsburgh, Dept Crit Care Med, Safar Ctr Resuscitat Res, Pittsburgh, PA 15219 USA; 2.Nanjing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Nanjing 210029, Jiangsu, Peoples R China; 3.Nanjing Med Univ, Affiliated Hosp 1, Dept Orthoped, Nanjing 210029, Jiangsu, Peoples R China; 4.Univ Pittsburgh, Ctr Free Rad & Antioxidant Hlth, Dept Environm & Occupat Hlth, Pittsburgh, PA 15219 USA; 5.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Food Safety Res, Shanghai 200031, Peoples R China; 6.Univ Chinese Acad Sci, CAS, Beijing 100049, Peoples R China; 7.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 8.Nanjing Univ, Sch Med, Dept Med Genet, Nanjing 210093, Jiangsu, Peoples R China; 9.Jiangsu Key Lab Mol Med, Nanjing 210029, Jiangsu, Peoples R China; 10.Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing 100022, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Chao, Honglu,Lin, Chao,Liu, Yinlong,et al. Cardiolipin-Dependent Mitophagy Guides Outcome after Traumatic Brain Injury[J]. JOURNAL OF NEUROSCIENCE,2019,39(10):1930-1943. |
| APA | Chao, Honglu.,Lin, Chao.,Liu, Yinlong.,Xu, Xiupeng.,Li, Zheng.,...&Bayir, Hulya.(2019).Cardiolipin-Dependent Mitophagy Guides Outcome after Traumatic Brain Injury.JOURNAL OF NEUROSCIENCE,39(10),1930-1943. |
| MLA | Chao, Honglu,et al."Cardiolipin-Dependent Mitophagy Guides Outcome after Traumatic Brain Injury".JOURNAL OF NEUROSCIENCE 39.10(2019):1930-1943. |
入库方式： OAI收割
来源：上海营养与健康研究所
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