PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy
文献类型：期刊论文
| 作者 | Cao, Qianqian2; You, Xue2; Xua, Lijiao2,3; Chen, Yan2,3; You, Xue3; Wang, Lin1; , |
| 刊名 | AUTOPHAGY
 |
| 出版日期 | 2020 |
| 卷号 | 16期号:7页码:1236-1247 |
| ISSN号 | 1554-8627 |
| 关键词 | ATG7 autophagy BECN1 EGFR lung cancer tumor suppressor |
| DOI | 10.1080/15548627.2019.1659654 |
| 文献子类 | Article |
| 英文摘要 | Macroautophagy/autophagy is an evolutionarily conserved intracellular process that recycles and degrades intracellular components to sustain homeostasis in response to deficiency of nutrients or growth factors. PAQR3 is a newly discovered tumor suppressor that also regulates autophagy induced by nutrient starvation via AMPK and MTORC1 signaling pathways. In this study, we investigated whether PAQR3 modulates EGFR-mediated autophagy and whether such regulation is associated with the tumor suppressive activity of PAQR3. PAQR3 is able to inhibit the in vitro and in vivo growth of non-small cell lung cancer (NSCLC) cells. PAQR3 potentiates autophagy induced by EGFR inhibitor erlotinib. Knockdown of PAQR3 abrogates erlotinib-mediated reduction of BECN1 interaction with autophagy inhibitory proteins RUBCN/Rubicon and BCL2. PAQR3 blocks the interaction of BECN1 with the activated form of EGFR and inhibits tyrosine phosphorylation of BECN1. Furthermore, inhibition of autophagy by knocking down ATG7 abrogates the tumor suppressive activity of PAQR3 in NSCLC cells. Collectively, these data indicate that PAQR3 suppresses tumor progression of NSCLC cells through modulating EGFR-regulated autophagy. |
| 学科主题 | Cell Biology |
| WOS关键词 | TUMOR-SUPPRESSOR ; RECEPTOR ; IDENTIFICATION ; PROGRESSION ; MUTATIONS ; GEFITINIB ; PLAYS ; GENE ; PI3K ; RAF |
| 语种 | 英语 |
| 出版者 | TAYLOR & FRANCIS INC |
| WOS记录号 | WOS:000484275900001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/535]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.China Anim Hlth & Epidemiol Ctr, Qingdao, Shandong, Peoples R China, 2.Univ Chinese Acad Sci, Chinese Acad Sci, CAS Key Lab Nutr Metab & Food Safety, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, Shanghai, Peoples R China; 3.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Cao, Qianqian,You, Xue,Xua, Lijiao,et al. PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy[J]. AUTOPHAGY,2020,16(7):1236-1247. |
| APA | Cao, Qianqian.,You, Xue.,Xua, Lijiao.,Chen, Yan.,You, Xue.,...&,.(2020).PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy.AUTOPHAGY,16(7),1236-1247. |
| MLA | Cao, Qianqian,et al."PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy".AUTOPHAGY 16.7(2020):1236-1247. |
入库方式： OAI收割
来源：上海营养与健康研究所
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