Peli1 negatively regulates noncanonical NF-kappa B signaling to restrain systemic lupus erythematosus
文献类型：期刊论文
| 作者 | Liu, Junli2; Hao, Shumeng2; Wang, Yan2; Xu, Jing2; Zhang, Xingli2; Yu, Tao2; Gan, Shucheng2; Zhang, Yanyun2; Shen, Nan2; Xiao, Yichuan2 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2018 |
| 卷号 | 9期号:-页码:1136 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-018-03530-3 |
| 文献子类 | Article |
| 英文摘要 | Systemic lupus erythematosus (SLE) is characterized by uncontrolled secretion of auto-antibodies by plasma cells. Although the functional importance of plasma cells and auto-antibodies in SLE has been well established, the underlying molecular mechanisms of controlling autoantibody production remain poorly understood. Here we show that Peli1 has a B cell-intrinsic function to protect against lupus-like autoimmunity in mice. Peli1 deficiency in B cells induces autoantibody production via noncanonical NF-kappa B signaling. Mechanically, Peli1 functions as an E3 ligase to associate with NF-kappa B inducing kinase (NIK) and mediates NIK Lys48 ubiquitination and degradation. Overexpression of Peli1 inhibits noncanonical NF-kappa B activation and alleviates lupus-like disease. In humans, PELI1 levels negatively correlate with disease severity in SLE patients. Our findings establish Peli1 as a negative regulator of the noncanonical NF-kappa B pathway in the context of restraining the pathogenesis of lupus-like disease. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | AUTOANTIBODY PRODUCTION ; CELL-ACTIVATION ; T-BET ; BAFF ; AUTOIMMUNITY ; KINASE ; TRAF3 ; SLE ; OVEREXPRESSION ; DISEASE |
| 语种 | 英语 |
| WOS记录号 | WOS:000427698700005 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/693]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Shanghai Inst Rheumatol, Shanghai Renji Hosp, Sch Med, Shanghai 200001, Peoples R China; 2.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci,Key Lab Stem Cell Biol, Shanghai 200031, Peoples R China; 3.Shanghai Jiao Tong Univ, Xin Hua Hosp, Sch Med, Dept Nephrol & Rheumatol, Shanghai 200092, Peoples R China; 4.Jiangsu Univ, Affiliated Hosp, Dept Nucl Med, 438 Jiefang Rd, Zhenjiang 212001, Peoples R China; 5.Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, Shanghai 200025, Peoples R China; 6.Fudan Univ, Shanghai Canc Ctr, Dept Med Oncol, Shanghai, Peoples R China; 7.Zhejiang Univ, Life Sci Inst, Hangzhou 310058, Zhejiang, Peoples R China; 8.Univ Texas MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA, |
| 推荐引用方式 GB/T 7714 | Liu, Junli,Hao, Shumeng,Wang, Yan,et al. Peli1 negatively regulates noncanonical NF-kappa B signaling to restrain systemic lupus erythematosus[J]. NATURE COMMUNICATIONS,2018,9(-):1136. |
| APA | Liu, Junli.,Hao, Shumeng.,Wang, Yan.,Xu, Jing.,Zhang, Xingli.,...&,.(2018).Peli1 negatively regulates noncanonical NF-kappa B signaling to restrain systemic lupus erythematosus.NATURE COMMUNICATIONS,9(-),1136. |
| MLA | Liu, Junli,et al."Peli1 negatively regulates noncanonical NF-kappa B signaling to restrain systemic lupus erythematosus".NATURE COMMUNICATIONS 9.-(2018):1136. |
入库方式： OAI收割
来源：上海营养与健康研究所
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