Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y(1) and P2Y(12) receptors (vol 8, 8084, 2018)
文献类型：期刊论文
| 作者 | Liu, Xuyang1,2,3,4; Wu, Yiran2; Stevens, Raymond C.2; Zhao, Suwen2,3; Gao, Zhan-Guo5; Jacobson, Kenneth A.5; , |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:-页码:11380 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-018-29406-6 |
| 文献子类 | Correction |
| 英文摘要 | The targeting range of CRISPR-Cas9 base editors (BEs) is limited by their G/C-rich protospacer-adjacent motif (PAM) sequences. To overcome this limitation, we developed a CRISPR-Cpf1-based BE by fusing the rat cytosine deaminase APOBEC1 to a catalytically inactive version of Lachnospiraceae bacterium Cpf1. The base editor recognizes a T-rich PAM sequence and catalyzes C-to-T conversion in human cells, while inducing low levels of indels, non-C-to-T substitutions and off-target editing. |
| 学科主题 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000439555700001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/718]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 2.ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China; 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai 20031, Peoples R China; 5.NIDDK, Mol Recognit Sect, Lab Bioorgan Chem, NIH, Bethesda, MD 20892 USA, |
| 推荐引用方式 GB/T 7714 | Liu, Xuyang,Wu, Yiran,Stevens, Raymond C.,et al. Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y(1) and P2Y(12) receptors (vol 8, 8084, 2018)[J]. SCIENTIFIC REPORTS,2018,8(-):11380. |
| APA | Liu, Xuyang.,Wu, Yiran.,Stevens, Raymond C..,Zhao, Suwen.,Gao, Zhan-Guo.,...&,.(2018).Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y(1) and P2Y(12) receptors (vol 8, 8084, 2018).SCIENTIFIC REPORTS,8(-),11380. |
| MLA | Liu, Xuyang,et al."Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y(1) and P2Y(12) receptors (vol 8, 8084, 2018)".SCIENTIFIC REPORTS 8.-(2018):11380. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。