Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y(1 )and P2Y(12) receptors
文献类型：期刊论文
| 作者 | Liu, Xuyang1,2,3,4; Wu, Yiran2; Stevens, Raymond C.2; Zhao, Suwen2,3; Gao, Zhan-Guo5; Jacobson, Kenneth A.5; , |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:-页码:8084 |
| ISSN号 | 2045-2322 |
| 关键词 | Tumors Classification algorithms Support vector machines Feature extraction Mice Metastasis Tumor metastasis patient-derived xenografts gene expression Monte Carlo feature selection support vector machine |
| DOI | 10.1038/s41598-018-26577-0 |
| 文献子类 | Article |
| 英文摘要 | Many hemorheologic Traditional Chinese Medicines (TCMs) that are widely-used clinically lack molecular mechanisms of action. We hypothesized that some of the active components of hemorheologic TCMs may function through targeting prothrombotic P2Y(1) and/or P2Y(12) receptors. The interactions between 253 antithrombotic compounds from TCM and these two G protein-coupled P2Y receptors were evaluated using virtual screening. Eleven highly ranked hits were further tested in radioligand binding and functional assays. Among these compounds, salvianolic acid A and C antagonized the activity of both P2Y(1 )and P2Y(12) receptors in the low mu M range, while salvianolic acid B antagonized the P2Y(12) receptor. These three salvianolic acids are the major active components of the broadly-used hemorheologic TCM Danshen (Salvia militorrhiza), the antithrombotic molecular mechanisms of which were largely unknown. Thus, the combination of virtual screening and experimental validation identified potential mechanisms of action of multicomponent drugs that are already employed clinically. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | PROTEIN-COUPLED RECEPTORS ; ACUTE CORONARY SYNDROMES ; ADENOSINE-DIPHOSPHATE RECEPTORS ; TARGET INTERACTION PREDICTION ; PLATELET-AGGREGATION ; ACCURATE DOCKING ; AQUEOUS EXTRACT ; DEPSIDE SALT ; FORCE-FIELD ; DRUG |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000432928200009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/841]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 2.ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China; 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai 20031, Peoples R China; 5.NIDDK, Mol Recognit Sect, Lab Bioorgan Chem, NIH, Bethesda, MD 20892 USA, |
| 推荐引用方式 GB/T 7714 | Liu, Xuyang,Wu, Yiran,Stevens, Raymond C.,et al. Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y(1 )and P2Y(12) receptors[J]. SCIENTIFIC REPORTS,2018,8(-):8084. |
| APA | Liu, Xuyang.,Wu, Yiran.,Stevens, Raymond C..,Zhao, Suwen.,Gao, Zhan-Guo.,...&,.(2018).Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y(1 )and P2Y(12) receptors.SCIENTIFIC REPORTS,8(-),8084. |
| MLA | Liu, Xuyang,et al."Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y(1 )and P2Y(12) receptors".SCIENTIFIC REPORTS 8.-(2018):8084. |
入库方式： OAI收割
来源：上海营养与健康研究所
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