中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y(1) and P2Y(12) receptors (vol 8, 8084, 2018)

文献类型:期刊论文

AuthorLiu, Xuyang1,3,4,5; Wu, Yiran3; Stevens, Raymond C.3; Zhao, Suwen3,4; Gao, Zhan-Guo2; Jacobson, Kenneth A.2; ,
SourceSCIENTIFIC REPORTS
Issued Date2018
Volume8Issue:-Pages:11380
KeywordmiR-630 Breast cancer BMI1 Apoptosis
ISSN2045-2322
DOI10.1038/s41598-018-29406-6
SubtypeCorrection
English AbstractMicroRNAs (miRNAs) play critical roles in breast cancer cell biological processes, including proliferation and apoptosis by inhibiting the expression of their target genes. Herein, we reported that miR-630 overexpression initiates apoptosis, blocks cell cycle progression and suppresses cell proliferation in breast cancer cells. Furthermore, BMI1, a member of polycomb group family, was identified as a direct target of miR-630, and there was a negative correlation between the expression levels of BMI1 and miR-630 in human breast cancer samples. With a series of biology approaches, subsequently, we proved that BMI1 was a functional downstream target of miR-630 and mediated the property of miR-630-dependent inhibition of breast cancer progression. Taken together, these findings provide further evidence on the tumor-suppression function of miR-630 in breast cancer, and clarify BMI1 as a novel functional target gene of miR-630.
SubjectScience & Technology - Other Topics
WOS KeywordDNA-DAMAGE RESPONSE ; CELL RENEWAL FACTOR ; SELF-RENEWAL ; MIR-630 ; CARCINOMA ; REPAIR ; UBIQUITYLATION ; PROLIFERATION ; METASTASIS ; EXPRESSION
Language英语
PublisherNATURE PUBLISHING GROUP
WOS IDWOS:000439555700001
Version出版稿
源URL[http://202.127.25.144/handle/331004/842]  
Collection中国科学院上海生命科学研究院营养科学研究所
Affiliation1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China;
2.NIDDK, Mol Recognit Sect, Lab Bioorgan Chem, NIH, Bethesda, MD 20892 USA,
3.ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China;
4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China;
5.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai 20031, Peoples R China;
Recommended Citation
GB/T 7714
Liu, Xuyang,Wu, Yiran,Stevens, Raymond C.,et al. Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y(1) and P2Y(12) receptors (vol 8, 8084, 2018)[J]. SCIENTIFIC REPORTS,2018,8(-):11380.
APA Liu, Xuyang.,Wu, Yiran.,Stevens, Raymond C..,Zhao, Suwen.,Gao, Zhan-Guo.,...&,.(2018).Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y(1) and P2Y(12) receptors (vol 8, 8084, 2018).SCIENTIFIC REPORTS,8(-),11380.
MLA Liu, Xuyang,et al."Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y(1) and P2Y(12) receptors (vol 8, 8084, 2018)".SCIENTIFIC REPORTS 8.-(2018):11380.

入库方式: OAI收割

来源:上海营养与健康研究所

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