Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y(1) and P2Y(12) receptors (vol 8, 8084, 2018)
文献类型:期刊论文
作者 | Liu, Xuyang1,3,4,5; Wu, Yiran3; Stevens, Raymond C.3; Zhao, Suwen3,4; Gao, Zhan-Guo2; Jacobson, Kenneth A.2; , |
刊名 | SCIENTIFIC REPORTS |
出版日期 | 2018 |
卷号 | 8期号:-页码:11380 |
ISSN号 | 2045-2322 |
关键词 | miR-630 Breast cancer BMI1 Apoptosis |
DOI | 10.1038/s41598-018-29406-6 |
文献子类 | Correction |
英文摘要 | MicroRNAs (miRNAs) play critical roles in breast cancer cell biological processes, including proliferation and apoptosis by inhibiting the expression of their target genes. Herein, we reported that miR-630 overexpression initiates apoptosis, blocks cell cycle progression and suppresses cell proliferation in breast cancer cells. Furthermore, BMI1, a member of polycomb group family, was identified as a direct target of miR-630, and there was a negative correlation between the expression levels of BMI1 and miR-630 in human breast cancer samples. With a series of biology approaches, subsequently, we proved that BMI1 was a functional downstream target of miR-630 and mediated the property of miR-630-dependent inhibition of breast cancer progression. Taken together, these findings provide further evidence on the tumor-suppression function of miR-630 in breast cancer, and clarify BMI1 as a novel functional target gene of miR-630. |
学科主题 | Science & Technology - Other Topics |
WOS关键词 | DNA-DAMAGE RESPONSE ; CELL RENEWAL FACTOR ; SELF-RENEWAL ; MIR-630 ; CARCINOMA ; REPAIR ; UBIQUITYLATION ; PROLIFERATION ; METASTASIS ; EXPRESSION |
语种 | 英语 |
出版者 | NATURE PUBLISHING GROUP |
WOS记录号 | WOS:000439555700001 |
版本 | 出版稿 |
源URL | [http://202.127.25.144/handle/331004/842] |
专题 | 中国科学院上海生命科学研究院营养科学研究所 |
作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 2.NIDDK, Mol Recognit Sect, Lab Bioorgan Chem, NIH, Bethesda, MD 20892 USA, 3.ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China; 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai 20031, Peoples R China; |
推荐引用方式 GB/T 7714 | Liu, Xuyang,Wu, Yiran,Stevens, Raymond C.,et al. Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y(1) and P2Y(12) receptors (vol 8, 8084, 2018)[J]. SCIENTIFIC REPORTS,2018,8(-):11380. |
APA | Liu, Xuyang.,Wu, Yiran.,Stevens, Raymond C..,Zhao, Suwen.,Gao, Zhan-Guo.,...&,.(2018).Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y(1) and P2Y(12) receptors (vol 8, 8084, 2018).SCIENTIFIC REPORTS,8(-),11380. |
MLA | Liu, Xuyang,et al."Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y(1) and P2Y(12) receptors (vol 8, 8084, 2018)".SCIENTIFIC REPORTS 8.-(2018):11380. |
入库方式: OAI收割
来源:上海营养与健康研究所
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