Short-term exposure to norfloxacin induces oxidative stress, neurotoxicity and microbiota alteration in juvenile large yellow croaker Pseudosciaena crocea
文献类型：期刊论文
| 作者 | Wang, Xinghuo1,2,3; Hu, Menghong1,3; Gu, Huaxin1,3; Zhang, Libin4,5; Shang, Yueyong1,3; Wang, Ting1,3; Wang, Tingyue1,3; Zeng, Jiangning2,4; Ma, Lukuo2; Huang, Wei2,4 |
| 刊名 | ENVIRONMENTAL POLLUTION
 |
| 出版日期 | 2020-12-01 |
| 卷号 | 267页码:9 |
| ISSN号 | 0269-7491 |
| 关键词 | AChE Fish Intestinal microbiota Norfloxacin Oxidative stress |
| DOI | 10.1016/j.envpol.2020.115397 |
| 通讯作者 | Huang, Wei(willhuang@sio.org.cn) |
| 英文摘要 | In recent years, antibiotics have been widely detected in coastal waters of China, which raising concerns for coastal biodiversity and aquaculture. This study evaluated the effects of short-term exposure of norfloxacin (NOR) on oxidative stress and intestinal health of the large yellow croaker Pseudosciaena crocea. Juvenile fish were exposed to four concentrations of NOR (0.1, 10, 100 and 1000 mu g/L) for 14 days. The results showed that NOR inhibited growth and threatened the survival of juveniles. According to the changes of intestinal microbiota, we found that NOR led to a significant decrease in intestinal microbiota diversity, with the decreased relative abundance of Proteobacteria, but the increased Tenericutes. From the perspective of microbial function, NOR inhibited metabolism, cellular defence mechanism and information transduction process. In terms of biochemical indicators, NOR caused an increase in malondialdehyde (MDA) level and inhibited superoxide dismutase (SOD) and acetyl cholinesterase (AChE) activities. Catalase (CAT) activity was activated at low concentration but significantly inhibited at high concentration of NOR. Moreover, there was a high correlation between change in biochemical indicators and change in the microbial community. Overall, environmentally relevant concentrations (0.1 mu g/L) and high concentrations (10, 100 and 1000 mu g/L) of NOR have negative effects on the defence function and intestinal health of large yellow croaker juveniles. (c) 2020 Elsevier Ltd. All rights reserved. |
| 资助项目 | National Key R&D Program of China[2019YFD0901101] ; National Key R&D Program of China[2018YFD0900901] ; State Key Laboratory of Satellite Ocean Environment Dynamics[SOEDZZ 1902] ; ChinaASEAN Maritime Cooperation Fund Project ; Joint Advanced Marine and Ecological Studies in the Bay of Bengal and the eastern equatorial Indian Ocean (JAMES) ; Key Projects of Philosophy and Social Sciences Research,Ministry of Education[18JZD059] ; ChinaAPEC Cooperation Fund[2029901] |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000593966000012 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/169471]  |
| 专题 | 海洋研究所_海洋生态与环境科学重点实验室 |
| 通讯作者 | Huang, Wei |
| 作者单位 | 1.Shanghai Ocean Univ, Minist Sci & Technol, Int Res Ctr Marine Biosci, Shanghai 201306, Peoples R China 2.Minist Nat Resources, Inst Oceanog 2, Key Lab Marine Ecosyst Dynam, Hangzhou 310012, Peoples R China 3.Shanghai Ocean Univ, Minist Educ, Key Lab Explorat & Utilizat Aquat Genet Resources, Shanghai 201306, Peoples R China 4.Minist Nat Resources, Inst Oceanog 2, State Key Lab Satellite Ocean Environm Dynam, Hangzhou 310012, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xinghuo,Hu, Menghong,Gu, Huaxin,et al. Short-term exposure to norfloxacin induces oxidative stress, neurotoxicity and microbiota alteration in juvenile large yellow croaker Pseudosciaena crocea[J]. ENVIRONMENTAL POLLUTION,2020,267:9. |
| APA | Wang, Xinghuo.,Hu, Menghong.,Gu, Huaxin.,Zhang, Libin.,Shang, Yueyong.,...&Wang, Youji.(2020).Short-term exposure to norfloxacin induces oxidative stress, neurotoxicity and microbiota alteration in juvenile large yellow croaker Pseudosciaena crocea.ENVIRONMENTAL POLLUTION,267,9. |
| MLA | Wang, Xinghuo,et al."Short-term exposure to norfloxacin induces oxidative stress, neurotoxicity and microbiota alteration in juvenile large yellow croaker Pseudosciaena crocea".ENVIRONMENTAL POLLUTION 267(2020):9. |
入库方式： OAI收割
来源：海洋研究所
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