Design, Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives Bearing Semicarbazone Moiety as Antitumor Agents
文献类型：期刊论文
| 作者 | Ma Junjie1; Hu Gang1; Xie Lijun2; Chen Lei1; Xu Boxuan1; Gong Ping1 |
| 刊名 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| 出版日期 | 2015 |
| 卷号 | 31期号:6页码:958-963 |
| 关键词 | POTENT INHIBITORS ONCRASIN-1 DISCOVERY Benzothiazole Semicarbazone Antitumor activity |
| ISSN号 | 1005-9040 |
| 其他题名 | Design, Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives Bearing Semicarbazone Moiety as Antitumor Agents |
| 英文摘要 | A series of novel benzothiazole derivatives bearing semicarbazone as a linker was designed and synthesized, and their in vitro antitumor activities were evaluated against four cancer cell lines(HT29, 11460, A549 and MDA-MB-231). Most of them showed moderate to excellent activity against all the tested cell lines. Among them, compounds 12a-12i with fluoro-substituted benzyl-1H-indole moiety displayed more potent activity than those with phenyl moiety. The most promising compound 12d exhibited excellent antitumor activity with IC50 values of 0.015, 0.28, 1.53 and 0.68 mu mol/L against the four tested cell lines respectively. |
| 资助项目 | [Program for Liaoning Excellent Talents in University, China] ; [National Natural Science Foundation of China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5586213 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/144338]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.中国科学院金属研究所 2.Fujian Institute Microbiol, Fuzhou 350007, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma Junjie,Hu Gang,Xie Lijun,et al. Design, Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives Bearing Semicarbazone Moiety as Antitumor Agents[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2015,31(6):958-963. |
| APA | Ma Junjie,Hu Gang,Xie Lijun,Chen Lei,Xu Boxuan,&Gong Ping.(2015).Design, Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives Bearing Semicarbazone Moiety as Antitumor Agents.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,31(6),958-963. |
| MLA | Ma Junjie,et al."Design, Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives Bearing Semicarbazone Moiety as Antitumor Agents".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 31.6(2015):958-963. |
入库方式： OAI收割
来源：金属研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。