Synthesis and Antitumor Activities of Novel 4-Morpholinothieno3,2-dpyrimidine Derivatives
文献类型：期刊论文
| 作者 | Song Kaizhen; Ma Junjie; Wang Xiao; Gong Ping; Zhao Yanfang |
| 刊名 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| 出版日期 | 2014 |
| 卷号 | 30期号:1页码:75-81 |
| 关键词 | CANCER POTENT INHIBITOR KINASE 2-Hydrazinyl-4-morpholinothieno3,2-dpyrimidine Antitumor activity Cytotoxic activity |
| ISSN号 | 1005-9040 |
| 其他题名 | Synthesis and Antitumor Activities of Novel 4-Morpholinothieno3,2-dpyrimidine Derivatives |
| 英文摘要 | A series of novel 2-hydrazinyl-4-morpholinothieno3,2-dpyrimidine derivatives was designed and synthesized. All of them were screened for their cytotoxic activities against large cell lung cancer(H460), colon cancer (HT-29) and adenocarcinomic lung cancer(A549) cell lines in vitro. The pharmacological results indicate that most of the target compounds show moderate to significant activities. Especially compound 17 exhibits the most potent antitumor activities against H460, HT-29 and A549 cell lines with IC50 values of 0.57, 0.45 and 1.45 mu mol/L, respectively. |
| 资助项目 | [Ministry of Education of China] ; [Program for Liaoning Innovative Research Team in University, China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5051263 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/146107]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Song Kaizhen,Ma Junjie,Wang Xiao,et al. Synthesis and Antitumor Activities of Novel 4-Morpholinothieno3,2-dpyrimidine Derivatives[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2014,30(1):75-81. |
| APA | Song Kaizhen,Ma Junjie,Wang Xiao,Gong Ping,&Zhao Yanfang.(2014).Synthesis and Antitumor Activities of Novel 4-Morpholinothieno3,2-dpyrimidine Derivatives.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,30(1),75-81. |
| MLA | Song Kaizhen,et al."Synthesis and Antitumor Activities of Novel 4-Morpholinothieno3,2-dpyrimidine Derivatives".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 30.1(2014):75-81. |
入库方式： OAI收割
来源：金属研究所
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