Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents
文献类型：期刊论文
| 作者 | Zhang Lan; Deng Xinshan; Wu Jiaofeng; Meng Guangpeng; Liu Congchong; Chen Guzhou; Zhao Qingchun; Hu Chun |
| 刊名 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| 出版日期 | 2017 |
| 卷号 | 33期号:3页码:365-372 |
| 关键词 | MOLECULAR TARGETED DRUGS TYROSINE KINASE CANCER-CELLS EGFR RESISTANCE POTENT DISCOVERY NSCLC Anticancer activity Epidemal growth factor receptor(EGFR) inhibitor N-( Furan-2-ylmethyl)-1H-indole3-carboxamide derivative |
| ISSN号 | 1005-9040 |
| 其他题名 | Design,Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents |
| 英文摘要 | A series of N-(furan-2-ylmethyl)-1H-indole-3-carboxamide derivatives(6a- 6p) was designed and synthesized for developing novel indole scaffolds as anticancer agents targeting the epidemal growth factor receptor (EGFR), and the cytotoxic activities of the target compounds were evaluated against three EGFR high- expressed cancer cell lines human lung adenocarcinoma cell line(A549), Henrietta Lacks strain of cancer cell line(HeLa) and human colorectal cancer cell line(SW480) |
| 资助项目 | [National Natural Science Foundation of China] ; [Program for the Innovative Research Team of the Ministry of Education of China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6018836 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/154003]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Zhang Lan,Deng Xinshan,Wu Jiaofeng,et al. Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2017,33(3):365-372. |
| APA | Zhang Lan.,Deng Xinshan.,Wu Jiaofeng.,Meng Guangpeng.,Liu Congchong.,...&Hu Chun.(2017).Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,33(3),365-372. |
| MLA | Zhang Lan,et al."Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 33.3(2017):365-372. |
入库方式： OAI收割
来源：金属研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。