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9,10-Anhydrodehydroartemisinin Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Th1 and Th17 Cell Differentiation

文献类型：期刊论文

作者Lv, Jie1; Zhuang, Wei1,2,3; Zhang, Yan4; Xie, Ling1; Xiang, Zhenglong1; Zhao, Qingjie5; Jiang, Xiangrui3,5; Shen, Jingshan3,6; Du, Changsheng1,6
刊名INFLAMMATION
出版日期2021-03-31
页码10
关键词9 10-Anhydrodehydroartemisinin artemisinin multiple sclerosis Th1 Th17 experimental autoimmune encephalomyelitis
ISSN号0360-3997
DOI10.1007/s10753-021-01456-5
通讯作者Jiang, Xiangrui(jiangxiangrui@simm.ac.cn) ; Du, Changsheng(duchangsheng@tongji.edu.cn)
英文摘要Human inflammatory disease, multiple sclerosis (MS), is a demyelinating disease of central nervous system (CNS). The experimental autoimmune encephalomyelitis (EAE) is the most commonly used as experimental model because of its key pathological features' approximation of MS. The interaction between complex elements in immune system and in the CNS determines the MS pathogenesis. However, there is no cure for MS and the treatment for MS still encounters great challenges. Thus, finding a more effective disease-modifying treatment is imminent. In the present study, we investigated whether 9,10-Anhydrodehydroartemisin (ADART), a compound derived from artemisinin, could decrease demyelination in EAE and the underlying mechanisms. In established EAE mice, 100 mg/kg 9,10-Anhydrodehydroartemisinin (ADART) effectively reduced CNS and peripheral immune system infiltration inflammatory cells including CD4(+) IFN-gamma(+) Th1 cells and CD4(+) IL-17A(+) Th17 cells. Correspondingly, the serum level of IFN-gamma and IL-17A was also reduced. In vitro, ADART almost completely inhibited Th17 differentiation, and partially inhibited Th1 differentiation in 10 mu M. This research revealed that ADART could be a great promising avenue among current therapies for MS.
资助项目National Natural Science Foundation of China[32070768] ; National Natural Science Foundation of China[31871404] ; National Natural Science Foundation of China[31900658] ; Special Foundation of Chinese Academy of Sciences for strategic pilot technology[XDA12040327] ; Shanghai Municipal Science and Technology Major Project[2017SHZDZX01] ; State Key Laboratory of Drug Research
WOS研究方向Cell Biology ; Immunology
语种英语
WOS记录号WOS:000635496800001
出版者SPRINGER/PLENUM PUBLISHERS
源URL[http://119.78.100.183/handle/2S10ELR8/295317]  
专题新药研究国家重点实验室
通讯作者Jiang, Xiangrui; Du, Changsheng
作者单位1.Tongji Univ, Putuo Peoples Hosp, Sch Life Sci & Technol, Shanghai Key Lab Signaling & Dis Res, Shanghai, Peoples R China
2.Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromol, Natl Lab Biomacromol, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, 40-1 Beijing Rd, Urumqi 830011, Xinjiang, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Lv, Jie,Zhuang, Wei,Zhang, Yan,et al. 9,10-Anhydrodehydroartemisinin Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Th1 and Th17 Cell Differentiation[J]. INFLAMMATION,2021:10.
APA Lv, Jie.,Zhuang, Wei.,Zhang, Yan.,Xie, Ling.,Xiang, Zhenglong.,...&Du, Changsheng.(2021).9,10-Anhydrodehydroartemisinin Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Th1 and Th17 Cell Differentiation.INFLAMMATION,10.
MLA Lv, Jie,et al."9,10-Anhydrodehydroartemisinin Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Th1 and Th17 Cell Differentiation".INFLAMMATION (2021):10.

入库方式： OAI收割

来源：上海药物研究所

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