A metal-free method for the facile synthesis of indanones via the intramotecular hydroacylation of 2-vinytbenzaldehyde
文献类型：期刊论文
| 作者 | He, Guoxue1,2,3; Ma, Jinyu2,3; Zhou, Jianhui2,3; Li, Chunpu2,3; Liu, Hong1,2,3 ; Zhou, Yu1,2,3
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| 刊名 | GREEN CHEMISTRY
 |
| 出版日期 | 2021-01-21 |
| 卷号 | 23期号:2页码:1036-1040 |
| ISSN号 | 1463-9262 |
| DOI | 10.1039/d0gc03572f |
| 通讯作者 | Liu, Hong(hliu@simm.ac.cn) ; Zhou, Yu(zhouyu@simm.ac.cn) |
| 英文摘要 | A facile method for the synthesis of indanones was developed under metal- and additive-free conditions, wherein L-proline served as an efficient and environmentally benign catalyst. Compared with previously synthesized indanones, synthesis by the transition-metal-catalyzed intramolecular hydroacylation of 2-vinylbenzaldehyde provided a more green synthetic pathway to indanone scaffolds with good to excellent yields. More importantly, it could be used to synthsize the anti-AD drug donepezil. |
| 资助项目 | National Natural Science Foundation of China[21977106] ; National Natural Science Foundation of China[21672232] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[81903434] ; Shanghai Science and Technology Development Funds[19431901000] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000613508300039 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/295624]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hong; Zhou, Yu |
| 作者单位 | 1.UCAS, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Guoxue,Ma, Jinyu,Zhou, Jianhui,et al. A metal-free method for the facile synthesis of indanones via the intramotecular hydroacylation of 2-vinytbenzaldehyde[J]. GREEN CHEMISTRY,2021,23(2):1036-1040. |
| APA | He, Guoxue,Ma, Jinyu,Zhou, Jianhui,Li, Chunpu,Liu, Hong,&Zhou, Yu.(2021).A metal-free method for the facile synthesis of indanones via the intramotecular hydroacylation of 2-vinytbenzaldehyde.GREEN CHEMISTRY,23(2),1036-1040. |
| MLA | He, Guoxue,et al."A metal-free method for the facile synthesis of indanones via the intramotecular hydroacylation of 2-vinytbenzaldehyde".GREEN CHEMISTRY 23.2(2021):1036-1040. |
入库方式： OAI收割
来源：上海药物研究所
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